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Leupeptins, new protease inhibitors from Actinomycetes.
Semisynthetic aminoglycoside antibiotics: Development and enzymatic modifications
Abstract The critical resistance mechanisms of aminoglycoside antibiotics in bacteria of clinical importance are the enzymatic N-acetylation, O-phosphorylation, and O-nucleotidylation that generally… Expand
A new antitumor antibiotic, spergualin: isolation and antitumor activity.
- T. Takeuchi, H. Iinuma, +7 authors H. Umezawa
- Biology, Medicine
- The Journal of antibiotics
- 1 December 1981
Sir: In testing the activity of culture filtrates to inhibit focus formation of chicken fibroblasts by Rous sarcoma virus, an antibiotic produced by a bacillus isolated from a soil sample collected… Expand
Letter: Syntheses of 1-n-(S)-4-amino-2-hydroxybutyryl)-kanamycin B and -3', 4'-dideoxykanamycin B active against kanamycin-resistant bacteria.
Inhibition of Acidic Sphingomyelinase by Xanthone Compounds Isolated from Garcinia Speciosa
- C. Okudaira, Y. Ikeda, +5 authors K. Umezawa
- Biology, Medicine
- Journal of enzyme inhibition
- 1 January 2000
Sphingomyelinase is considered to be involved in the regulation of apoptosis and cell growth. In the course of our screening for acidic sphingomyelinase inhibitors we isolated three xanthone… Expand
A new trisaccharide, α-d-glucopyranuronosyl-(1→3)-α-l-rhamnopyranosyl-(1→2)-α-l-rhamnopyranose from Chlorella vulgaris
Abstract A new acidic trisaccharide, α- d -glucopyranuronosyl-(1→3)-α- l -rhamnopyranosyl-(1→2)-α- l -rhamnopyranose, was isolated from the hydrolyzate of an acidic polysaccharide, glucuronorhamnan,… Expand
MINOSAMINOMYCIN, A NEW ANTIBIOTIC CONTAINING MYO-INOSAMINE
Production and isolation of a new antibiotic: kanamycin.
Structure of an antitumor antibiotic, spergualin.
Purification and properties of kanamycin-phosphorylating enzyme from Pseudomonas aeruginosa.