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The cellular response to neuregulins is governed by complex interactions of the erbB receptor family
- D. Riese, T. van Raaij, G. Plowman, G. Andrews, D. Stern
- BiologyMolecular and cellular biology
- 1 October 1995
The results provide the first comprehensive analysis of the response of this receptor family to a single peptide agonist and demonstrate the existence of several previously undocumented receptor interactions driven by neuregulin.
The ErbB-2/HER2 oncoprotein of human carcinomas may function solely as a shared coreceptor for multiple stroma-derived growth factors.
- L. Klapper, S. Glathe, Y. Yarden
- BiologyProceedings of the National Academy of Sciences…
- 27 April 1999
Oncogenicity of ErbB-2 in human epithelia may not rely on the existence of a specific ligand but rather on its ability to act as a coreceptor for multiple stroma-derived growth factors.
Epiregulin Is a Potent Pan-ErbB Ligand That Preferentially Activates Heterodimeric Receptor Complexes*
It is found that epiregulin is the broadest specificity EGF-like ligand so far characterized: not only does it stimulate homodimers of both ErbB-1 and Erbb-4, it also activates all possible heterodimericErbB complexes.
Neuregulin-4: a novel growth factor that acts through the ErbB-4 receptor tyrosine kinase
The primary structure and the pattern of expression of NRG-4 suggest a physiological role distinct from that of the known ErbB ligands, as well as the strict specificity of this growth factor to ErbbB-4.
Topology of the pore-region of a K+ channel revealed by the NMR-derived structures of scorpion toxins
Heregulin induces in vivo proliferation and differentiation of mammary epithelium into secretory lobuloalveoli.
- F. Jones, D. J. Jerry, B. C. Guarino, G. Andrews, D. Stern
- BiologyCell growth & differentiation : the molecular…
- 1 August 1996
The overall mammary response to growth factors was potentiated by the concomitant presence of E/P, and the in vivo mammary epithelial responses to HRG alpha were more robust than TGF-alpha.
ErbB Tyrosine Kinases and the Two Neuregulin Families Constitute a Ligand-Receptor Network
It is concluded that the NRG-ErbB network represents a complex and nonredundant machinery developed for fine-tuning of signal transduction.
Pathogenic poxviruses reveal viral strategies to exploit the ErbB signaling network
It is reported that the growth factors of Shope fibroma virus, Myxoma virus and vaccinia virus display unique patterns of specificity to ErbB receptor tyrosine kinases, which imply that signal potentiation and precise targeting to specific receptor combinations contribute to cell transformation at sites of poxvirus infection.
The Structural Basis for the Specificity of Epidermal Growth Factor and Heregulin Binding (*)
- E. Barbacci, B. C. Guarino, G. Andrews
- Biology, ChemistryThe Journal of Biological Chemistry
- 21 April 1995
The synthesis of heregulin β 177-241 is reported and it is shown that a region consisting of amino acids 177-226 is sufficient both for binding and stimulation of receptor phosphorylation.
Amylin and CGRP induce insulin resistance via a receptor distinct from cAMP-coupled CGRP receptor.
- D. Kreutter, S. Oreña, A. Torchia, L. Contillo, G. Andrews, R. W. Stevenson
- Biology, ChemistryThe American journal of physiology
- 1 April 1993
The results demonstrate that the inhibition of insulin-stimulated glucose transport by amylin is independent of cAMP and may be mediated by a unique receptor that is distinct from the adenylyl cyclase-coupled CGRP receptor.