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Selegiline

Known as: L-Deprenyl, (-)-selegiline, Selegiline [Chemical/Ingredient] 
A selective, irreversible inhibitor of Type B monoamine oxidase. It is used in newly diagnosed patients with Parkinson's disease. It may slow… 
National Institutes of Health

Related topics

Related topics

29 relations

Narrower (10)

4-fluorodeprenylDeprenylE-250Eldepryl
Alzheimer's DiseaseAttention deficit hyperactivity disorderDepressive disorderDrug Allergy

Broader (3)

Antiparkinson AgentsMonoamine Oxidase InhibitorsNeuroprotective Agents

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2001
2001
Future of neuroprotection in Parkinson's disease.
Highly Cited
2000
Highly Cited
2000
Selegiline and desmethylselegiline stimulate NGF, BDNF, and GDNF synthesis in cultured mouse astrocytes.
We investigated the effects of selegiline and desmethylselegiline on synthesis of neurotrophic factors in cultured mouse… 
1998
1998
l-deprenyl-induced increase in IL-2 and NK cell activity accompanies restoration of noradrenergic nerve fibers in the spleens of old F344 rats
Review
1997
Review
1997
Parkinson's disease: prospects for improved drug therapy.
Highly Cited
1991
Highly Cited
1991
Selegiline (deprenyl) treatment and death of nigral neurons in Parkinson's disease
We studied the effect of selegiline (deprenyl) treatment on the number of Lewy bodies and neuron counts in the substantia nigra… 
Highly Cited
1989
Highly Cited
1989
Chronic L-deprenyl-induced up-regulation of the dopamine uptake carrier.
Highly Cited
1988
Highly Cited
1988
Formation of the Neurotransmitter Glycine from the Anticonvulsant Milacemide Is Mediated by Brain Monoamine Oxidase B
Abstract: Milacemide (2‐n‐pentylaminoacetamide) is a secondary monoamine that in the brain is converted to glycinamide and… 
1988
1988
Amino Acid Availability and Brain Function in Health and Disease
Until the early seventies, it was generally believed that normal brain function would be unaffected by the metabolic changes… 
Highly Cited
1980
Highly Cited
1980
L-deprenyl, a selective monoamine oxidase type-B inhibitor in endogenous depression.
Highly Cited
1980
Highly Cited
1980
The monoamine oxidase inhibitors clorgyline and L-deprenyl also affect the uptake of dopamine, noradrenaline and serotonin by rat brain synaptosomal preparations.
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