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Orexin A activates locus coeruleus cell firing and increases arousal in the rat.
- J. Hagan, R. Leslie, N. Upton
- Biology, PsychologyProceedings of the National Academy of Sciences…
- 14 September 1999
It is shown that the brain region receiving the densest innervation from orexinergic nerves is the locus coeruleus, a key modulator of attentional state, where application of orexIn A increases cell firing of intrinsic noradrenergic neurones and modulates neuroendocrine function.
Pharmacological actions of a novel, high-affinity, and selective human dopamine D(3) receptor antagonist, SB-277011-A.
- C. Reavill, S. Taylor, J. Hagan
- Biology, ChemistryThe Journal of pharmacology and experimental…
- 1 September 2000
The effect of SB-277011-A on isolation-induced prepulse inhibition deficit suggests that blockade of dopamine D(3) receptors may benefit the treatment of schizophrenia.
Characterization of SB‐269970‐A, a selective 5‐HT7 receptor antagonist
A role for 5‐HT7 receptor stimulation in 5‐CT induced hypothermia in guinea‐pigs is suggested, and time spent in Paradoxical Sleep (PS) during the first 3 h of EEG recording in conscious rats is significantly reduced.
Dopamine D3 Receptor Antagonism Inhibits Cocaine-Seeking and Cocaine-Enhanced Brain Reward in Rats
An important role for D3 receptors in mediating the addictive properties of cocaine is suggested and blockade of dopamine D3receptors may constitute a new and useful target for prospective pharmacotherapies for cocaine addiction.
Analysis of gene expression in two large schizophrenia cohorts identifies multiple changes associated with nerve terminal function
Changes were observed in gene sets associated with synaptic vesicle recycling, transmitter release and cytoskeletal dynamics that strongly suggests multiple, small but synergistic changes in gene expression that affect nerve terminal function.
A novel, potent, and selective 5-HT(7) antagonist: (R)-3-(2-(2-(4-methylpiperidin-1-yl)ethyl)pyrrolidine-1-sulfonyl) phen ol (SB-269970).
Long-lasting changes in behavioural and neuroendocrine indices in the rat following neonatal maternal separation: Gender-dependent effects
A systematic, genome-wide, phenotype-driven mutagenesis programme for gene function studies in the mouse
A genome-wide, phenotype-driven screen for dominant mutations in the mouse is undertaken, which has led to a substantial increase in themouse mutant resource and represents a first step towards systematic studies of gene function in mammalian genetics.
Use of SHIRPA and discriminant analysis to characterise marked differences in the behavioural phenotype of six inbred mouse strains
Isolation rearing induces recognition memory deficits accompanied by cytoskeletal alterations in rat hippocampus
- M. Bianchi, K. Fone, N. Azmi, C. Heidbreder, J. Hagan, C. Marsden
- Biology, PsychologyThe European journal of neuroscience
- 1 November 2006
Findings are indicative of an abnormal development of synaptic connections and/or reductions in neuronal cell number in the hippocampus which may contribute to the cognitive impairments which result from isolation rearing in rats.