Deprenyl

 
National Institutes of Health

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Highly Cited
2012
Highly Cited
2012
UNLABELLED Astrocytes colocalize with fibrillar amyloid-β (Aβ) plaques in postmortem Alzheimer disease (AD) brain tissue. It is… (More)
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Review
2004
Review
2004
Deprenyl, the selective irreversible inhibitor of monoamine oxidase-B (MAO-B), has been synthesised as a potential antidepressant… (More)
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Highly Cited
2002
Highly Cited
2002
Deprenyl (selegiline) delays the need for levodopa therapy in patients with early Parkinson's disease, but the long-term benefits… (More)
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Review
2001
Review
2001
Free radicals and other so-called 'reactive species' are constantly produced in the brain in vivo. Some arise by 'accidents of… (More)
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Highly Cited
1999
Highly Cited
1999
1. There are differences between the excitotoxic actions of quinolinic acid and N-methyl-D-aspartate (NMDA) which suggest that… (More)
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Highly Cited
1991
Highly Cited
1991
Daily s.c. injection of (-)deprenyl (2.0 mg/kg/day) for three weeks in young male rats caused a threefold increase in superoxide… (More)
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Highly Cited
1989
Highly Cited
1989
  • The New England journal of medicine
  • 1989
In a clinical trial that is still in progress, we studied the ability of deprenyl and tocopherol, antioxidative agents that act… (More)
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Highly Cited
1989
Highly Cited
1989
Tissue glutathione disulfide (GSSG) was studied as an index of changes in redox state in the striatum. When increased turnover of… (More)
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Highly Cited
1985
Highly Cited
1985
In an open, uncontrolled study the longterm (9 years) effect of treatment with Madopar® alone (n=377) or in combination with l… (More)
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Highly Cited
1977
Highly Cited
1977
In a double-blind crossover trial, (-)-deprenyl, a fast-acting selective monoamine-oxidase-B inhibitor without a "cheese effect… (More)
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