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Deprenyl

 
National Institutes of Health

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Highly Cited
2012
Highly Cited
2012
Astrocytes colocalize with fibrillar amyloid-β (Aβ) plaques in postmortem Alzheimer disease (AD) brain tissue. It is therefore of… Expand
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Highly Cited
2002
Highly Cited
2002
Monoamine oxidase B (MAO B) is a mitochondrial outermembrane flavoenzyme that is a well-known target for antidepressant and… Expand
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Review
2001
Review
2001
Free radicals and other so-called ‘reactive species’ are constantly produced in the brain in vivo. Some arise by ‘accidents of… Expand
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Highly Cited
1999
Highly Cited
1999
There are differences between the excitotoxic actions of quinolinic acid and N‐methyl‐D‐aspartate (NMDA) which suggest that… Expand
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Highly Cited
1996
Highly Cited
1996
The Deprenyl and Tocopherol Antioxidant Therapy of Parkinsonism (DATATOP) trial was designed to test outcomes from treatment with… Expand
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Highly Cited
1995
Highly Cited
1995
We have performed a 14‐month, prospective, randomized, double‐blind, placebo‐controlled study to evaluate the effect of deprenyl… Expand
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Highly Cited
1993
Highly Cited
1993
BACKGROUND AND METHODS In 1987 we began a multicenter controlled clinical trial of deprenyl (a monoamine oxidase inhibitor) and… Expand
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Highly Cited
1989
Highly Cited
1989
In a clinical trial that is still in progress, we studied the ability of deprenyl and tocopherol, antioxidative agents that act… Expand
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Highly Cited
1989
Highly Cited
1989
The effects of MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine), a neurotoxin that produces the symptoms of Parkinson's… Expand
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Highly Cited
1984
Highly Cited
1984
The neurotoxic chemical MPTP (1-methyl-4-phenyl-1,2,4,5-tetrahydropyridine) is metabolized by rat brain mitochondrial fractions… Expand
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