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Serotonin transporter promoter gain-of-function genotypes are linked to obsessive-compulsive disorder.
The HTTLPR L(A)L( a) genotype exerts a moderate effect on risk of OCD, which crystallizes the evidence that the HTT gene has a role in OCD.
Population and familial association between the D4 dopamine receptor gene and measures of Novelty Seeking
- J. Benjamin, Lin Li, C. Patterson, B. Greenberg, D. Murphy, D. Hamer
- Psychology, BiologyNature Genetics
The relationship between DADR exon III sequence variants and personality test scores in a population of 315 mostly male siblings, other family members and individuals from the United States was investigated and the association between long alleles ofExon III and personality traits related to Novelty Seeking was confirmed.
Altered brain serotonin homeostasis and locomotor insensitivity to 3, 4-methylenedioxymethamphetamine ("Ecstasy") in serotonin transporter-deficient mice.
Data suggest that the presence of a functional 5-HTT is essential for brain 5- HT homeostasis and for 3,4-methylenedioxymethamphetamine-induced hyperactivity.
Simultaneous genotyping of four functional loci of human SLC6A4, with a reappraisal of 5-HTTLPR and rs25531
Simultaneous genotyping of four functional loci of human SLC6A4 , with a reappraisal of 5-HTTLPR and rs25531 shows good agreement with previous work on this topic.
Genetic variation in the serotonin transporter promoter region affects serotonin uptake in human blood platelets.
- B. Greenberg, T. Tolliver, S. Huang, Q. Li, D. Bengel, D. Murphy
- Biology, PsychologyAmerican journal of medical genetics
- 5 February 1999
5-HT uptake findings support a functional difference in the two 5-HTTLPR variants, reinforcing their attractiveness as candidate genes in neuropsychiatric research.
Impaired Stress-Coping and Fear Extinction and Abnormal Corticolimbic Morphology in Serotonin Transporter Knock-Out Mice
The present findings demonstrate a specific phenotypic profile of fear- and stress-related deficits in 5-HTT KO mice, accompanied by morphological abnormalities in two key neural loci, and identify potential neural substrates underlying these phenotypes.
Cocaine reward models: conditioned place preference can be established in dopamine- and in serotonin-transporter knockout mice.
- I. Sora, C. Wichems, G. Uhl
- Biology, PsychologyProceedings of the National Academy of Sciences…
- 23 June 1998
It is reported that knockout mice without DAT and mice without 5-HTT establish cocaine-conditioned place preferences, which have substantial implications for understanding cocaine actions and for strategies to produce anticocaine medications.
Serotonin transporter: gene, genetic disorders, and pharmacogenetics.
Replicated studies have demonstrated that the SERT 5'-flanking region polymorphism SS genotype is associated with poorer therapeutic responses and more frequent serious side effects during treatment with antidepressant SERT antagonists, namely, the serotonin reuptake inhibitors (SRIs).
Obsessive–compulsive disorder symptom dimensions show specific relationships to psychiatric comorbidity
Targeting the murine serotonin transporter: insights into human neurobiology
Mutations resulting in reduced or completely abrogated serotonin-transporter (SERT) function in mice have led to the identification of more than 50 different phenotypic changes, ranging from…