Monoamine Oxidase Inhibitors
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Monoamine oxidase inhibitors were among the first antidepressants to be discovered and have long been used as such. It now seems… Expand All available antidepressant medications are based on serendipitous discoveries of the clinical efficacy of two classes of… Expand A few years after the foundation of the British Pharmacological Society, monoamine oxidase (MAO) was recognized as an enzyme of… Expand Toxicity resulting from excessive intra-synaptic serotonin, historically referred to as serotonin syndrome, is now understood to… Expand A genetic contribution to the pathogenesis of panic disorder has been demonstrated by clinical genetic studies. Molecular genetic… Expand 1-Methyl-4-phenyl-1,2,5,6-tetrahydropyridine (MPTP) causes degeneration of the dopaminergic nigrostriatal pathway in several… Expand A depressed state can be induced in mice by forcing them to swim in a narrow cylinder from which they cannot escape. After a… Expand Abstract— The effect of l‐tryptophan loading upon the amount of 5‐HT accumulating in the brains of rats pretreated with a… Expand The "catecholamine hypothesis of affective disorders" proposes that some, if not all, depressions are associated with an absolute… Expand