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Atomoxetine Increases Extracellular Levels of Norepinephrine and Dopamine in Prefrontal Cortex of Rat: A Potential Mechanism for Efficacy in Attention Deficit/Hyperactivity Disorder
Comparative Affinity of Duloxetine and Venlafaxine for Serotonin and Norepinephrine Transporters in vitro and in vivo, Human Serotonin Receptor Subtypes, and Other Neuronal Receptors
Cdc42-interacting Protein 4 Mediates Binding of the Wiskott-Aldrich Syndrome Protein to Microtubules*
It is concluded that CIP4 can mediate the association of WASP with microtubules, which may facilitate transport of WasP to sites of substrate adhesion in hematopoietic cells.
Soluble interleukin 2 receptors are released from activated human lymphoid cells in vitro.
The release of soluble IL 2R appears to be a characteristic marker of T lymphocyte activation and might serve an immunoregulatory function during both normal and abnormal cell growth and differentiation.
Preclinical pharmacological profile of the selective 5-HT1F receptor agonist lasmiditan
Lasmiditan presents a unique pyridinoyl-piperidine scaffold not found in any other antimigraine class, whose chemical structure and pharmacological profile clearly distinguish it from the triptans.
Pharmacologic Characterization of the Cloned Human Trace Amine-Associated Receptor1 (TAAR1) and Evidence for Species Differences with the Rat TAAR1
- D. B. Wainscott, S. Little, D. Nelson
- Biology, ChemistryJournal of Pharmacology and Experimental…
- 1 January 2007
The TAAR1 receptor exhibits a pharmacologic profile uniquely different from those of classic monoaminergic receptors, consistent with the structural information that places them in a distinct family of receptors, and suggests the potential for development of TAAR-selective agonists and antagonists to study their physiologic roles.
Mutations of the Wiskott-Aldrich Syndrome Protein (WASP): hotspots, effect on transcription, and translation and phenotype/genotype correlation.
By analyzing a large number of patients with WAS/XLT at the molecular level, 5 mutational hotspots in the WASP gene are identified and a strong association between genotype and phenotype is established.
Altered leukocyte response to CXCL12 in patients with warts hypogammaglobulinemia, infections, myelokathexis (WHIM) syndrome.
The altered leukocyte response to CXCL12 may account for the pathologic retention of mature polymorphonuclear cells in the bone marrow (myelokathexis) and for an altered lymphocyte trafficking, which may cause the immunophenotyping abnormalities observed in WHIM patients.
The soluble interleukin-2 receptor: biology, function, and clinical application.
It is suggested that sIL-2R levels offer a rapid, reliable, and noninvasive measure of disease activity, response to therapy, and, in some cases, prognosis in a broad spectrum of conditions associated with T- or B-cell immune activation.
Transactivation of interleukin 2 and its receptor induces immune activation in human T-cell lymphotropic virus type I-associated myelopathy: pathogenic implications and a rationale for immunotherapy.
- C. Tendler, S. Greenberg, D. Nelson
- Biology, MedicineProceedings of the National Academy of Sciences…
- 1 July 1990
The results suggest that immune activation in HAM/TSP, in contrast to ATL, is virally driven by the transactivation and coordinate expression of IL-2 andIL-2R alpha, which may contribute to the evolution of inflammatory nervous system damage in HAM /TSP.