Electrophysiological, biochemical, neurohormonal and behavioural studies with WAY-100635, a potent, selective and silent 5-HT1A receptor antagonist
- A. Fletcher, E. A. Forster, C. Dourish
- Biology, ChemistryBehavioural Brain Research
- 15 December 1995
Serotonin transporter overexpression is responsible for pulmonary artery smooth muscle hyperplasia in primary pulmonary hypertension.
- S. Eddahibi, M. Humbert, S. Adnot
- Biology, MedicineJournal of Clinical Investigation
- 15 October 2001
It is concluded that 5-HTT activity plays a key role in the pathogenesis of PA-SMC proliferation in PPH and that a 5HTT polymorphism confers susceptibility to PPH.
Somatodendritic localization of 5‐HT1A and preterminal axonal localization of 5‐HT1B serotonin receptors in adult rat brain
- M. Riad, S. Garcia, L. Descarries
- BiologyThe Journal of comparative neurology
- 7 February 2000
The localization of 5‐HT1B receptors to the membrane of preterminal axons suggests that they control transmitter release from nonserotonin as well as serotonin neurons by mediating serotonin effects on axonal conduction.
International Union of Pharmacology. XII. Classification of opioid receptors.
- B. Dhawan, F. Cesselin, M. Hamon
- MedicinePharmacological Reviews
- 1 December 1996
The results show that data from published knowledge can be used to provide reliable, patient level, automated risk assessment, potentially reducing the cognitive burden on physicians and helping policy makers better prepare for future needs.
International Union of Pharmacology. XXI. Structure, distribution, and functions of cholecystokinin receptors.
The peptide cholecystokinin has been shown to mediate pancreatic secretion and contraction of gallbladder and was described in the mammalian central nervous system (CNS) as a gastrin-like peptide.
Disruption of the nonneuronal tph1 gene demonstrates the importance of peripheral serotonin in cardiac function
- F. Côté, E. Thévenot, G. Vodjdani
- BiologyProceedings of the National Academy of Sciences…
- 3 November 2003
It is established that the neuronal tph2 is expressed in neurons of the raphe nuclei and of the myenteric plexus, whereas the nonneuronal tph1, as detected by β-galactosidase expression, is in the pineal gland and the enterochromaffin cells.
Neurotransmitter transporters in the central nervous system.
- J. Masson, C. Sagné, M. Hamon, S. El Mestikawy
- BiologyPharmacological Reviews
- 1 September 1999
Intercellular communication in the central nervous system (CNS)2 requires the precise control of the duration and the intensity of neurotransmitter action at specific molecular targets. After they…
Altered expression and functions of serotonin 5‐HT1A and 5‐HT1B receptors in knock‐out mice lacking the 5‐HT transporter
- V. Fabre, C. Beaufour, M. Martres
- BiologyEuropean Journal of Neuroscience
- 1 July 2000
Quantification of [35S]GTP‐γ‐S binding evoked by potent 5‐HT1 receptor agonists confirmed changes as a decrease in this parameter was noted in the DRN (−66%) and the substantia nigra (−30%) but not other brain areas in 5‐ HTT–/– vs. 5-HTT+/+ mice.
VGLUT3 (Vesicular Glutamate Transporter Type 3) Contribution to the Regulation of Serotonergic Transmission and Anxiety
- B. Amilhon, E. Lepicard, S. El Mestikawy
- BiologyJournal of Neuroscience
- 10 February 2010
It is found that deletion of VGLUT3 increased several anxiety-related behaviors in adult and in newborn mice as early as 8 d after birth and the results suggest that the loss of V GLUT3 expression leads to anxiety-associated behaviors and should be considered as a potential new target for the treatment of this disorder.
The selective 5-HT1A antagonist radioligand [3H]WAY 100635 labels both G-protein-coupled and free 5-HT1A receptors in rat brain membranes.
- H. Gozlan, S. Thibault, A. Laporte, L. Lima, M. Hamon
- Biology, ChemistryEuropean Journal of Pharmacology
- 16 January 1995
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