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Clinical research criteria for the diagnosis of progressive supranuclear palsy (Steele-Richardson-Olszewski syndrome)
To improve the specificity and sensitivity of the clinical diagnosis of progressive supranuclear palsy (PSP, Steele-Richardson-Olszewski syndrome), the National Institute of Neurological DisordersExpand
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Manganese neurotoxicity: a review of clinical features, imaging and pathology.
Manganese intoxication can result in a syndrome of parkinsonism and dystonia. If these extrapyramidal findings are present, they are likely to be irreversible and even progress after termination ofExpand
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In vivo positron emission tomographic evidence for compensatory changes in presynaptic dopaminergic nerve terminals in Parkinson's disease
Clinical symptoms of Parkinson's disease (PD) do not manifest until dopamine (DA) neuronal loss reaches a symptomatic threshold. To explore the mechanisms of functional compensation that occur inExpand
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Assessment of Parkinson's Disease
The quantitative assessment of clinical deficits in Parkinson's disease has become more difficult due to such factors as the introduction of therapy that induces involuntary movements, theExpand
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Expectation and Dopamine Release: Mechanism of the Placebo Effect in Parkinson's Disease
The power of placebos has long been recognized for improving numerous medical conditions such as Parkinson's disease (PD). Little is known, however, about the mechanism underlying the placebo effect.Expand
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Manganism and idiopathic parkinsonism
From the comparison we have made between PD and manganism, we draw the following conclusions: 1. There are similarities between PD and manganism, notably the presence of (a) generalized bradykinesiaExpand
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Criteria for diagnosing Parkinson's disease
Parkinson's disease evolves slowly, and there is current interest in exploring the earliest stages of the disorder, because of new approaches to studying pathogenesis and developing potentialExpand
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Age‐dependent decline of dopamine D1 receptors in human brain: A PET study
Radioligand binding studies in animals have demonstrated age‐related loss of dopamine receptors in the caudate and putamen. In humans, while age‐related declines in dopamine D2 receptors have beenExpand
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Manganese intoxication in the rhesus monkey
We gave three adult rhesus monkeys seven IV injections of manganese chloride at approximate 1-week intervals. We evaluated neurologic status by serial clinical examinations and performed a levodopaExpand
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Reaction time in Parkinson's disease.
Both reaction time and movement time tend to be prolonged in Parkinson's disease, but they are often impaired independently of each other. Prolongation of RT is relatively slight, while MT undergoesExpand
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