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Entacapone enhances the response to levodopa in parkinsonian patients with motor fluctuations
Objective: To study the effect and safety of entacapone as an adjunct to levodopa treatment in patients with PD with wearing-off motor fluctuations. Background: Entacapone is aExpand
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Changing epidemiology of Parkinson’s disease in southwestern Finland
Objective: Investigation of the epidemiology of PD in southwestern Finland in 1992 (population 196,864), including urban and rural areas, with a comparison with a similar study, done in the same areaExpand
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Dementia in Parkinson's disease is related to neuronal loss in the medial substantia nigra
Regional neuronal loss in the substantia nigra was studied in relation to extrapyramidal symptoms and dementia in 12 patients with idiopathic Parkinson's disease(PD) and in 18 control subjects. FourExpand
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The quality of life in Parkinson's disease
The objective of this study was to examine the quality of life in patients with Parkinson's disease (PD) in a community‐based sample (n = 228 patients) using a Medical Outcomes Study 36‐Item ShortExpand
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Entacapone prolongs levodopa response in a one month double blind study in parkinsonian patients with levodopa related fluctuations.
OBJECTIVES--To establish, in a double blind manner, the antiparkinsonian effects of repeated dosing with entacapone, a peripheral COMT inhibitor. METHODS--A one month, cross over study was conducted.Expand
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Pharmacokinetics and metabolism of selegiline.
Selegiline is readily absorbed from the gastrointestinal tract. It is distributed rapidly into the tissues, including the brain. It is the L-form of selegiline that is an active MAO-B inhibitor, theExpand
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Survival and cause of death in Alzheimer's disease and multi‐infarct dementia
ABSTRACT Survival and causes of death of 218 patients with Alzheimer's disease (AD) and of 115 patients with multi‐infarct dementia (MID) were examined. The patients were originally found in aExpand
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Essential tremor in a Finnish population
A two‐phase epidemiological study of essential tremor was carried out by investigating a rural population aged over 40 years in 2 municipalities in southwestern Finland. In the first phase, theExpand
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Slowing of Information Processing in Parkinson′s Disease
In this study, we criticize the notion of bradyphrenia and argue that "slowness of thought" in Parkinson's disease (PD) must be analyzed as slowness of different information-processing stages andExpand
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Autonomic dysfunction in recent onset and advanced Parkinson's disease
Cardiovascular autonomic nerve function and its relation to the clinical variables of untreated recent onset and levodopa-treated advanced disease parkinsonian patients were studied. Heart rateExpand
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