Parkinsonism, premature menopause, and mitochondrial DNA polymerase γ mutations: clinical and molecular genetic study
- P. Luoma, A. Melberg, A. Suomalainen
- Medicine, BiologyThe Lancet
- 4 September 2004
The A1 allele of the human D2 dopamine receptor gene predicts low D2 receptor availability in healthy volunteers
- T. Pohjalainen, J. Rinne, J. Hietala
- Biology, MedicineMolecular Psychiatry
- 1 May 1998
The association between the A1 allele and low D2 receptor availability in healthy subjects indicates that the A 1 allele of the TaqIA polymorphism might be in linkage disequilibrium with a mutation in the promoter/regulatory gene element that affects dopamine D2 receptors expression.
Amyloid load in Parkinson’s disease dementia and Lewy body dementia measured with [11C]PIB positron emission tomography
- P. Edison, C. Rowe, D. Brooks
- Medicine, BiologyJournal of Neurology Neurosurgery & Psychiatry
- 24 July 2008
It is suggested that the presence of amyloid in DLB could contribute to the rapid progression of dementia in this condition and that anti-amyloid strategies may be relevant.
11C-PiB PET assessment of change in fibrillar amyloid-β load in patients with Alzheimer's disease treated with bapineuzumab: a phase 2, double-blind, placebo-controlled, ascending-dose study
- J. Rinne, D. Brooks, M. Rossor, Nick C Fox, M. Grundman
- MedicineLancet Neurology
- 1 April 2010
C957T polymorphism of the dopamine D2 receptor (DRD2) gene affects striatal DRD2 availability in vivo
- M. Hirvonen, A. Laakso, K. Någren, J. Rinne, T. Pohjalainen, J. Hietala
- BiologyMolecular Psychiatry
- 27 July 2004
C957T polymorphism of the dopamine D2 receptor (DRD2) gene affects striatal DRD2 availability in vivo and this results in down-regulation inhibition of D2 receptors in the striatal area of the brain.
Corticobasal degeneration. A clinical study of 36 cases.
- J. Rinne, M. S. Lee, P. Thompson, C. Marsden
- Medicine, PsychologyBrain : a journal of neurology
- 1 October 1994
Gait difficulties and a supranuclear ophthalmoplegia had emerged in most patients and dysarthria and pyramidal signs were common and higher mental function was relatively preserved in most and a cortical sensory loss was evident in a quarter of cases.
Prevalence of cerebral amyloid pathology in persons without dementia: a meta-analysis.
- Willemijn J. Jansen, R. Ossenkoppele, H. Zetterberg
- Medicine, PsychologyJAMA
- 19 May 2015
Among persons without dementia, the prevalence of cerebral amyloid pathology as determined by positron emission tomography or cerebrospinal fluid findings was associated with age, apolipoprotein E [APOE] genotype, sex, and education, and presence of cognitive impairment.
Conversion of amyloid positive and negative MCI to AD over 3 years
- A. Okello, J. Koivunen, D. Brooks
- Medicine, BiologyNeurology
- 8 September 2009
PIB-positive subjects with mild cognitive impairment (MCI) are significantly more likely to convert to AD than PIB-negative patients, faster converters having higher PIB retention levels at baseline than slower converters.
Sex differences in the striatal dopamine D2 receptor binding characteristics in vivo.
- T. Pohjalainen, J. Rinne, K. Någren, E. Syvälahti, J. Hietala
- Medicine, PsychologyAmerican Journal of Psychiatry
- 1 June 1998
The results confirm the age-related reduction of D2 receptor density and binding potential in both sexes in vivo and suggest an increased endogenous striatal dopamine concentration in women.
The translating brain: cerebral activation patterns during simultaneous interpreting
- J. Rinne, J. Tommola, M. Sunnari
- Psychology, BiologyNeuroscience Letters
- 17 November 2000
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