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Pharmacokinetics of systemically administered cocaine and locomotor stimulation in mice.
Cocaine and its metabolites were measured in plasma and brain from mice injected i.p. with cocaine and monitored for spontaneous locomotor behavior. Cocaine concentrations in the brain reached peakExpand
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Cocaine disposition in the brain after continuous or intermittent treatment and locomotor stimulation in mice.
Intermittent s.c. and i.p. injections of cocaine (20 mg/kg; total 430 mg/kg for each animal) for 18 days resulted in locomotor stimulation of mice upon challenge with cocaine on the 25th or 26th day,Expand
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Effect of nicotine on levels of extracellular amino acids in regions of the rat brain in vivo
The local effect of nicotine on the extracellular levels of amino acids was examined in the striatum and frontal cortex of rats using microdialysis in vivo. The perfusion of 1 mM nicotine in Ringer'sExpand
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Brain Research
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Receptors in the Ventral Tegmental Area Mediating Nicotine-Induced Dopamine Release in the Nucleus Accumbens
Nicotine or cocaine, when administered intravenously, induces an increase of extracellular dopamine in the nucleus accumbens. The nicotine-mediated increase was shown to occur at least in partExpand
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Nicotine-Induced Changes in Neurotransmitter Levels in Brain Areas Associated with Cognitive Function
Nicotine, one of the most widespread drugs of abuse, has long been shown to impact areas of the brain involved in addiction and reward. Recent research, however, has begun to explore the positiveExpand
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The presence of free D-aspartic acid in rodents and man.
Free D-aspartic acid is present in appreciable quantities in the brain and other tissues of rodents and in human blood. In the newborn rat, the highest concentration of D-aspartic acid was found inExpand
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Effect of nicotine on extracellular levels of neurotransmitters assessed by microdialysis in various brain regions: Role of glutamic acid
We studied the effect of local administration of nicotine on the release of monoamines in striatum, substantia nigra, cerebellum, hippocampus, cortex (frontal, cingulate), and pontine nucleus and onExpand
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The periaqueductal gray: Site of morphine analgesia and tolerance as shown by 2-way cross tolerance between systemic and intracerebral injections
The periaqueductal gray was shown to be an important component of morphine analgesia and tolerance. Two-way analgesic cross tolerance was obtained between systemic and intracerebral morphineExpand
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