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Neuroprotective Agents

Known as: Neuroprotectants, Neuroprotective Agent, neuroprotective drug 
Drugs intended to prevent damage to the brain or spinal cord from ischemia, stroke, convulsions, or trauma. Some must be administered before the… Expand
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2013
Review
2013
Traumatic brain injury (TBI) is a leading cause of mortality and morbidity both in civilian life and on the battlefield worldwide… Expand
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Review
2009
Review
2009
Acute ischemic stroke is the third leading cause of death in industrialized countries and the most frequent cause of permanent… Expand
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Highly Cited
2006
Highly Cited
2006
Preclinical evaluation of neuroprotectants fostered high expectations of clinical efficacy. When not matched, the question arises… Expand
Review
2003
Review
2003
Background and Purpose— The National Institutes of Health (NIH) estimates that stroke costs now exceed $45 billion per year… Expand
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Highly Cited
2002
Highly Cited
2002
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) damages the nigrostriatal dopaminergic pathway as seen in Parkinson's disease… Expand
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Review
2002
Review
2002
Background— Neuroprotective drugs for acute stroke have appeared to work in animals, only to fail when tested in humans. With the… Expand
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Review
1999
Review
1999
The plethora of failed clinical trials with neuroprotective drugs for acute ischemic stroke have raised justifiable concerns… Expand
Highly Cited
1999
Highly Cited
1999
BACKGROUND AND PURPOSE The Barthel Index (BI) and the Modified Rankin Scale (MRS) are commonly used scales that measure… Expand
Highly Cited
1998
Highly Cited
1998
The neuroprotective actions of cannabidiol and other cannabinoids were examined in rat cortical neuron cultures exposed to toxic… Expand
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Highly Cited
1990
Highly Cited
1990
2,3-Dihydroxy-6-nitro-7-sulfamoyl-benzo(F)quinoxaline (NBQX) is an analog of the quinoxalinedione antagonists to the non-N-methyl… Expand