Propentofylline: a nucleoside transport inhibitor with neuroprotective effects in cerebral ischemia.

@article{Parkinson1994PropentofyllineAN,
  title={Propentofylline: a nucleoside transport inhibitor with neuroprotective effects in cerebral ischemia.},
  author={F. Parkinson and K. Rudolphi and B. Fredholm},
  journal={General pharmacology},
  year={1994},
  volume={25 6},
  pages={
          1053-8
        }
}
1. Adenosine is an endogenous neuroprotective agent; stimulation of A1 receptors decreases excitatory amino acid neurotransmission and stimulation of A2 receptors inhibits platelet and neutrophil activation and promotes vasodilation. 2. Post-ischemic administration of propentofylline (HWA 285) reduces neuronal damage in gerbils and improves glucose metabolism in all regions of brain in acute stroke patients. 3. Propentofylline inhibits the transport of adenosine into cultured cells and… Expand
Chapter 11 Adenosine and Neuroprotection
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Modulation of neuronal and glial cell function by adenosine and neuroprotection in vascular demential
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Effect of propentofylline on cerebral blood flow in a gerbil focal cerebral ischemia
TLDR
Investigation of the effect of propentofylline on regional cerebral blood flow in the gerbil permanent focal cerebral ischemia model suggests that propent ofylline at suitable dosage improves rCBF in ischemic brain areas. Expand
Possible therapeutic benefits of adenosine-potentiating drugs in reducing age-related degenerative disease in dogs and cats.
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The therapeutic potential of adenosine-potentiating drugs in the treatment of age-related conditions in companion animals, some of which may be exacerbated by castration or spaying at an early age are reviewed. Expand
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References

SHOWING 1-10 OF 36 REFERENCES
Inhibitory effects of propentofylline on [3H]adenosine influx. A study of three nucleoside transport systems.
TLDR
It is demonstrated that propentofylline is an inhibitor of adenosine transport processes and suggested that its neuroprotective effects may be due to an increase in extracellular concentrations ofAdenosine by virtue of inhibition of es transporter function. Expand
Propentofylline and Other Adenosine Transport Inhibitors Increase the Efflux of Adenosine Following Electrical or Metabolic Stimulation of Rat Hippocampal Slices
TLDR
The results indicate that nucleoside transport inhibitors can decrease the release of purines from cells and at the same time increase the concentration of extracellular adenosine, possibly by preventing its uptake and subsequent metabolism. Expand
Propentofylline and a hydroxy metabolite augment A2-receptor mediated cyclic AMP accumulation and attenuate A1-receptor mediated inhibition of acetylcholine release in the rat hippocampus.
TLDR
Propentofylline and one of its metabolites inhibits adenosine A1-receptor mediated presynaptic inhibition while it enhances adenosines A2-mediated cAMP accumulation in the rat hippocampus differently. Expand
Autoradiographical Studies of in Vitro and Chronic in Vivo Effects of Propentofylline on Adenosine A1 and A2 Receptors and NBMPR-Sensitive Nucleoside Transporters
Abstract Propentofylline is a novel xanthine that has been shown to limit the extent neuronal damage induced by cerebral ischemia in gerbils (DeLeo et al., 1987). This is in contrast to otherExpand
Stimulation of nerve growth factor synthesis/secretion by propentofylline in cultured mouse astroglial cells
Abstract The xanthine derivative propentofylline has been reported to exhibit protective effects on neuronal cells in the brain, which include improvement of impaired learning and memory andExpand
Further evidence that propentofylline (HWA 285) influences both adenosine receptors and adenosine transport
TLDR
The present results show that propent ofylline and its hydroxylated metabolite can influence adenosine mechanisms in a multitude of ways and how these different actions may contribute to the ability of propentofylline to reduce the magnitude of ischemic damage. Expand
Adenosine and brain ischemia.
TLDR
Adenosine acting via A2-receptors in brain vessels, platelets, and neutrophilic granulocytes may improve the cerebral microcirculation and thus oxygen and substrate supply to the tissue, and there is evidence that the functional state of adenosine receptors is impaired during ischemia, limiting the time window of theadenosine action. Expand
Protective effect of adenosine and a novel xanthine derivative propentofylline on the cell damage after bilateral carotid occlusion in the gerbil hippocampus
TLDR
The role of adenosine in the development of ischemia induced pathological changes has been examined in Mongolian gerbils and the use of theophylline and propentofylline significantly enhanced the ischemIA induced changes. Expand
Effect of propentofylline (HWA 285) on extracellular purines and excitatory amino acids in CA1 of rat hippocampus during transient ischaemia
TLDR
The present data show that propentofylline enhances extracellular adenosine and lowers Extracellular glutamate in vivo during ischaemia, which may be important in relation to the neuroprotective properties of propent ofylline. Expand
Effects of propentofylline on energy metabolism of the ischemic brain studied by in vivo 31P nuclear magnetic resonance spectroscopy.
TLDR
The present results suggest that propentofylline may accelerate the energy recovery of the transiently ischemic brain and suppress the development of post-ischemic cerebral edema. Expand
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