Propentofylline: a nucleoside transport inhibitor with neuroprotective effects in cerebral ischemia.

@article{Parkinson1994PropentofyllineAN,
  title={Propentofylline: a nucleoside transport inhibitor with neuroprotective effects in cerebral ischemia.},
  author={F. Parkinson and K. Rudolphi and B. Fredholm},
  journal={General pharmacology},
  year={1994},
  volume={25 6},
  pages={
          1053-8
        }
}
1. Adenosine is an endogenous neuroprotective agent; stimulation of A1 receptors decreases excitatory amino acid neurotransmission and stimulation of A2 receptors inhibits platelet and neutrophil activation and promotes vasodilation. 2. Post-ischemic administration of propentofylline (HWA 285) reduces neuronal damage in gerbils and improves glucose metabolism in all regions of brain in acute stroke patients. 3. Propentofylline inhibits the transport of adenosine into cultured cells and… Expand
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