• Publications
  • Influence
Regulation of antioxidant enzymes: a significant role for melatonin
TLDR
This report reviews the studies which document the influence of melatonin on the activity and expression of the antioxidative enzymes glutathione peroxidase, superoxide dismutases and catalase both under physiological and under conditions of elevated oxidative stress and analyses the possible mechanisms by which melatonin regulates these enzymes. Expand
One molecule, many derivatives: A never‐ending interaction of melatonin with reactive oxygen and nitrogen species?
TLDR
This review focuses on melatonin metabolism which includes the synthetic rate‐limiting enzymes, synthetic sites, potential regulatory mechanisms, bioavailability in humans, mechanisms of breakdown and functions of its metabolites. Expand
Pineal melatonin: cell biology of its synthesis and of its physiological interactions.
  • R. Reiter
  • Biology, Medicine
  • Endocrine reviews
  • 1 May 1991
TLDR
The pineal gland can be rapidly removed from rodents with minimal damage to adjacent neural structures using a specially designed trephine, and since the mid 1960s, research on the gland has become a very active area of investigation. Expand
Oxidative damage in the central nervous system: protection by melatonin
  • R. Reiter
  • Medicine, Chemistry
  • Progress in Neurobiology
  • 1 October 1998
TLDR
Melatonin has been shown prophylactically to reduce amyloid beta protein toxicity of Alzheimer's disease, to reduce oxidative damage in several models of Parkinson's disease and to protect against glutamate excitotoxicity. Expand
Melatonin and the ovary: physiological and pathophysiological implications.
TLDR
Melatonin could become an important medication for improving ovarian function and oocyte quality, and open new opportunities for the management of several ovarian diseases. Expand
Actions of Melatonin in the Reduction of Oxidative Stress
Melatonin was discovered to be a direct free radical scavenger less than 10 years ago. Besides its ability to directly neutralize a number of free radicals and reactive oxygen and nitrogen species,Expand
Chemical and physical properties and potential mechanisms: melatonin as a broad spectrum antioxidant and free radical scavenger.
TLDR
Under in vivo conditions, melatonin is often several times more potent than vitamin C and E in protecting tissues from oxidative injury when compared at an equivalent dosage (micromol/kg). Expand
Actions of melatonin in the reduction of oxidative stress. A review.
Melatonin was discovered to be a direct free radical scavenger less than 10 years ago. Besides its ability to directly neutralize a number of free radicals and reactive oxygen and nitrogen species,Expand
Melatonin as an antioxidant: biochemical mechanisms and pathophysiological implications in humans.
TLDR
Melatonin's functions as an antioxidant include: a), direct free radical scavenging, b), stimulation of antioxidative enzymes, c), increasing the efficiency of mitochondrial oxidative phosphorylation and reducing electron leakage (thereby lowering free radical generation), and 3), augmenting the efficiencyof other antioxidants. Expand
The melatonin rhythm: both a clock and a calendar
  • R. Reiter
  • Biology, Medicine
  • Experientia
  • 15 August 1993
TLDR
The paper summarizes the 3 patterns of nocturnal melatonin production that have been described and shows that the circadian production and secretion of melatonin by the pineal gland can impart both daily and seasonal, i.e., calendar, information to the organism. Expand
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