Melatonin: New Places in Therapy

@article{Maharaj2007MelatoninNP,
  title={Melatonin: New Places in Therapy},
  author={Deepa Sukhdev Maharaj and Beverley D. Glass and Santy Daya},
  journal={Bioscience Reports},
  year={2007},
  volume={27},
  pages={299-320}
}
The fact that the full extent of the function of the pineal gland has not yet been elucidated, has stimulated melatonin research worldwide. This review introduces melatonin’s mechanism of action, direct and indirect antioxidant actions as well as the antioxidant properties of its metabolites, 6-hydroxymelatonin (6-OHM) and N-acetyl-N-formyl-5-methoxykynurenamine (AFMK). At present the mechanism of action is proposed to be receptor-, protein- and nonprotein-mediated. From its popular role in the… 
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References

SHOWING 1-10 OF 153 REFERENCES
Suppression of oxygen toxicity by melatonin.
TLDR
Melatonin is highly effective in reducing nuclear DNA damage and membrane lipid destruction due to toxic free radicals in vivo and have implications for disease processes, eg, neurodegenerative and cardiovascular diseases, which involve free radicals and for aging itself, which also is believed to be related to accumulated oxidative damage.
Significance of Melatonin in Antioxidative Defense System: Reactions and Products
TLDR
Melatonin in plants not only provides an alternative exogenous source of melatonin for herbivores but also suggests that melatonin may be an important antioxidant in plants which protects them from a hostile environment that includes extreme heat, cold and pollution, all of which generate free radicals.
Evaluation of the antioxidant activity of melatonin in vitro.
Melatonin, active oxygen species and neurological damage.
  • R. Reiter
  • Biology
    Drug news & perspectives
  • 1998
TLDR
Melatonin has been shown to protect against a large number of models of neurodegeneration in animals that involve free radical damage; however, clinical studies using this molecule have yet to be performed.
Oxidative damage in the central nervous system: protection by melatonin
  • R. Reiter
  • Biology
    Progress in Neurobiology
  • 1998
Actions of melatonin in the reduction of oxidative stress. A review.
Melatonin was discovered to be a direct free radical scavenger less than 10 years ago. Besides its ability to directly neutralize a number of free radicals and reactive oxygen and nitrogen species,
Melatonin involvement in oxidative processes.
TLDR
The study of the correlation between the dose of melatonin with highest pro-oxidative properties and the various peroxide concentrations in the generating system showed that melatonin gets antioxidative properties with the increase in peroxide concentration.
Pharmacology and Physiology of Melatonin in the Reduction of Oxidative Stress in vivo
TLDR
The evidence is summarized which shows that melatonin is a significant free radical scavenger and antioxidant at both physiological and pharmacological concentrations in vivo, considered in terms of neurodegenerative diseases, cancer, ischemia/reperfusion injury and aging.
...
1
2
3
4
5
...