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Lack of effect of induction of hypothermia after acute brain injury.
Treatment with hypothermia, with the body temperature reaching 33 degrees C within eight hours after injury, is not effective in improving outcomes in patients with severe brain injury.
A controlled cortical impact model of traumatic brain injury in the rat
Very early hypothermia induction in patients with severe brain injury (the National Acute Brain Injury Study: Hypothermia II): a randomised trial
A phase II study of moderate hypothermia in severe brain injury.
Forty-six patients with severe nonpenetrating brain injury [Glasgow Coma Scale (GCS) 4-7] were randomized to standard management at 37 degrees C (n = 22) and to standard management with systemic…
Clinical trials in head injury.
This workshop proved to be very informative and yielded many insights into previous and future TBI trials, and it is hoped that these lessons will enhance the planning and design of future efforts in this important field of research.
Guidelines for the management of severe head injury. Brain Trauma Foundation.
Prolonged memory impairment in the absence of hippocampal cell death following traumatic brain injury in the rat
Marked Protection by Moderate Hypothermia after Experimental Traumatic Brain Injury
- G. Clifton, J. Jiang, B. Lyeth, L. Jenkins, R. Hamm, R. Hayes
- BiologyJournal of cerebral blood flow and metabolism…
- 1 January 1991
Hypothermia-treated rats had significantly less beam-walking beam-balance, and body weight loss deficits compared to normothermic (38°C) rats, and the greatest protection was observed in the 30°C hypothermia group.
Sulforaphane enhances aquaporin‐4 expression and decreases cerebral edema following traumatic brain injury
It is suggested that the reduction of brain edema in response to SUL administration could be due, in part, to water clearance by AQP4 from the injured brain.