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4-carboxy-3-hydroxyphenylglycine

Known as: 4-CHPGly 
 
National Institutes of Health

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Related topics

3 relations

Broader (2)

GlycineNeuroprotective Agents
analogs & derivatives

Papers overview

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Highly Cited
2001
Highly Cited
2001
Neuroprotection mediated by glial group-II metabotropic glutamate receptors requires the activation of the MAP kinase and the phosphatidylinositol-3-kinase pathways.
The mGlu2/3 receptor agonists 4-carboxy-3-hydroxyphenylglycine (4C3HPG) and LY379268 attenuated NMDA toxicity in primary cultures… Expand
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Highly Cited
2000
Highly Cited
2000
Selective blockade of mGlu5 metabotropic glutamate receptors protects rat hepatocytes against hypoxic damage
Western blot analysis of protein extracts from rat liver revealed the presence of the mGlu5 receptor, one of the G‐protein… Expand
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Highly Cited
2000
Highly Cited
2000
Neuroprotection by metabotropic glutamate receptor agonists on kainate-induced degeneration of motor neurons in spinal cord slices from adult rat
Research has provided evidence about the role of excitotoxicity in the pathophysiology of sporadic amyotrophic lateral sclerosis… Expand
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2000
2000
Some metabotropic glutamate receptor ligands reduce kynurenate synthesis in rats by intracellular inhibition of kynurenine aminotransferase II.
Some metabotropic glutamate receptor (mGluR) ligands, such as quisqualate, L-(+)-2-amino-4-phosphonobutyric acid (L-AP4), 4… Expand
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Highly Cited
1995
Highly Cited
1995
Phenylglycine derivatives discriminate between mGluR1- and mGluR5-mediated responses
The effects of the phenylglycine derivatives, alpha-methyl-4-carboxyphenylglycine (MCPG), 4-carboxyphenylglycine (4CPG), 4… Expand
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Highly Cited
1995
Highly Cited
1995
Metabotropic Glutamate Receptors Inhibiting Excitatory Synapses in the CA1 Area of Rat Hippocampus
In the CA1 region of hippocampal slices prepared from young adult rats, we studied the ability of several specific agonists of… Expand
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Highly Cited
1994
Highly Cited
1994
Analysis of agonist and antagonist activities of phenylglycine derivatives for different cloned metabotropic glutamate receptor subtypes
The metabotropic glutamate receptors (mGluRs) consist of at least seven different subtypes and are coupled to intracellular… Expand
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1994
1994
Actions of (1S,3R)-1-aminocyclopentane-1,3-dicarboxylic acid (1S,3R- ACPD) in retinal ON bipolar cells indicate that it is an agonist at L- AP4 receptors
Metabotropic glutamate receptors (mGluRs) include receptors sensitive to L-2-amino-4-phosphonobutyrate (L-AP4) and 1S,3R-1… Expand
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1994
1994
Analysis of Derivatives Subtypes Agonist and Antagonist Activities of Phenylglycine for Different Cloned Metabotropic Glutamate Receptor
The metabotropic glutamate receptors (mGluRs) consist of at least seven different subtypes and are coupled to intracellular… Expand
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1993
1993
4-Carboxy-3-hydroxyphenylglycine, an antagonist at type I metabotropic glutamate receptors.
The pharmacology of (DL)-4-carboxy-3-hydroxyphenylglycine was examined in baby hamster kidney cells which stably express the type… Expand
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