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Assessment of voiding dysfunction in Parkinson's disease by the international prostate symptom score.
  • I. Araki, S. Kuno
  • Medicine
  • Journal of neurology, neurosurgery, and…
  • 1 April 2000
OBJECTIVES To find the incidence of voiding dysfunction in Parkinson's disease and to examine the relation between the voiding dysfunction and various indices of the disease (disease severity,Expand
Riluzole stimulates nerve growth factor, brain-derived neurotrophic factor and glial cell line-derived neurotrophic factor synthesis in cultured mouse astrocytes
Riluzole is an antiexcitotoxic agent used for the treatment of amyotrophic lateral sclerosis, and reported to have neuroprotective effects in animal models of Parkinson's disease, Huntington'sExpand
The effect of dopamine agonists: The expression of GDNF, NGF, and BDNF in cultured mouse astrocytes
In Parkinson's disease, cell death is selectively induced in mesencephalic nigral dopaminergic neurons. At present, no disease modifying therapy or radical treatment has been found for this disease.Expand
Caspase activities and tumor necrosis factor receptor R1 (p55) level are elevated in the substantia nigra from Parkinsonian brain
Summary. The activities of caspase-1 and caspase-3 were measured by use of fluoropeptides as substrates for the first time in the brain (substantia nigra, caudate nucleus, putamen, cerebellum, andExpand
Voiding dysfunction and Parkinson's disease: urodynamic abnormalities and urinary symptoms.
PURPOSE We evaluated bladder dysfunction and Parkinson's disease in regard to disease severity and determined whether subjective patient urinary symptoms correlated with urodynamic abnormalities. Expand
Clinical efficacy of istradefylline (KW‐6002) in Parkinson's disease: A randomized, controlled study
The objectives of this study were to evaluate the efficacy of istradefylline at an oral dose of 20 mg or 40 mg once daily for 12 weeks in Parkinson's disease (PD) patients with motor complications onExpand
Selegiline and desmethylselegiline stimulate NGF, BDNF, and GDNF synthesis in cultured mouse astrocytes.
We investigated the effects of selegiline and desmethylselegiline on synthesis of neurotrophic factors in cultured mouse astrocytes. Treatment with 2 mM selegiline for 24 h increased the contents ofExpand
Tumor necrosis factor gene polymorphisms in patients with sporadic Parkinson's disease
We studied promoter region polymorphisms in the tumor necrosis factor (TNF) gene at position -1031, -863, and -857, in 172 Japanese patients with sporadic Parkinson's disease (PD). The frequency ofExpand
Brain‐derived neurotrophic factor gene polymorphisms in Japanese patients with sporadic Alzheimer's disease, Parkinson's disease, and multiple system atrophy
We studied two genetic polymorphisms (240C/T and 480G/A) of the brain‐derived neurotrophic factor (BDNF) gene in Japanese patients with Alzheimer's disease (AD, n = 172), Parkinson's disease (PD, n =Expand
Contribution of the interleukin-1beta gene polymorphism in multiple system atrophy.
We studied genetic polymorphisms in the promoter region at position -511 of the interleukin (IL) -1beta gene (IL-1B-511) and at position -889 of the IL-1alpha gene (IL-1A-889), in 111 JapaneseExpand