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Effects of transcranial direct current stimulation (tDCS) on cognition, symptoms, and smoking in schizophrenia: A randomized controlled study
TLDR
The positive effects of tDCS on cognitive performance suggest a potential efficacious treatment for cognitive deficits in partially recovered chronic schizophrenia outpatients that should be further investigated. Expand
Receptors in the Ventral Tegmental Area Mediating Nicotine-Induced Dopamine Release in the Nucleus Accumbens
TLDR
The findings indicate that a number of receptors in the ventral tegmental area mediate nicotine-induced dopamine changes in the nucleus accumbens, a major component of the nicotine reward mechanism. Expand
Functional connectivity fMRI in mouse brain at 7T using isoflurane
TLDR
This work reports for the first time that reliable functional connectivity measures in mouse brain can be obtained with isoflurane and reports measures of functional connectivity in mice using only isofLurane for the anesthetic. Expand
Reversal of Phencyclidine-Induced Dopaminergic Dysregulation by N-Methyl-D-Aspartate Receptor/Glycine-site Agonists
TLDR
Findings demonstrate effective doses of glycine for use in animal models of schizophrenia, and support recent clinical studies showing the effectiveness of NMDA agonists in the treatment of persistent symptoms of schizophrenia. Expand
Nicotine-Induced Changes in Neurotransmitter Levels in Brain Areas Associated with Cognitive Function
TLDR
In conclusion, acute nicotine administration caused alterations in the levels of DA, 5-HT, and NE, and in the metabolism of DA and 5- HT, in brain areas that are involved in cognitive processes, and appeared to increase the release and turnover of these three neurotransmitters. Expand
Characterization of nicotinic receptors involved in the release of noradrenaline from the hippocampus
TLDR
The results suggest the possible involvement of alpha 3 and beta 2 nicotinic acetylcholine receptor subunits in the control of [3H]noradrenaline release from hippocampal slices. Expand
Effect of nicotine on extracellular levels of neurotransmitters assessed by microdialysis in various brain regions: Role of glutamic acid
TLDR
The fact that kynurenic acid almost completely prevented the effects of nicotine, and nicotine at this concentration produced a 6-fold increase of glutamic acid release, suggests that the effect of nicotine is mainly mediated via glutamic Acid release. Expand
Inhibition of System A-mediated glycine transport in cortical synaptosomes by therapeutic concentrations of clozapine: implications for mechanisms of action
TLDR
System A transporters, or a subset thereof, may play a critical role in regulation of synaptic glycine levels and by extension of NMDA receptor regulation, and second that System A antagonism may contribute to the differential clinical efficacy of clozapine compared with other typical or atypical antipsychotics. Expand
Cognitive and antismoking effects of varenicline in patients with schizophrenia or schizoaffective disorder
TLDR
Treatment with varenicline may not increase psychopathology or depression in most patients with schizophrenia, but longer studies are needed to determine whether it will produce rates of smoking abstinence similar to those found in control smokers. Expand
Specific Calpain Inhibition by Calpastatin Prevents Tauopathy and Neurodegeneration and Restores Normal Lifespan in Tau P301L Mice
TLDR
This work reports a striking rescue from mutant tau toxicity in the JNPL3 mouse model of tauopathy, and shows that pathological activation of calpains gives rise to a range of potentially toxic forms of t Tau, directly, and by activating cdk5. Expand
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