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Pyrimethamine / Sulfadoxine

Known as: PYRIMETHAMINE/SULFADOXINE, sulphadoxine-pyrimethamine, fanasil, pyrimethamine drug combination 
A combination product containing pyrimethamine and sulfadoxine. Pyrimethamine is a competitive inhibitor of dihydrofolate reductase (DHFR). DHFR is a… 
National Institutes of Health

Related topics

Related topics

5 relations

Broader (2)

AntimalarialsDrug Combinations
PyrimethamineSulfadoxine

Narrower (1)

Suldox

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2014
Review
2014
The rise and fall of malaria in a West African rural community, Dielmo, Senegal, from 1990 to 2012: a 22 year longitudinal study.
Review
2011
Review
2011
Changes in health workers' malaria diagnosis and treatment practices in Kenya
BackgroundChange of Kenyan treatment policy for uncomplicated malaria from sulphadoxine-pyrimethamine to artemether-lumefantrine… 
Highly Cited
2007
Highly Cited
2007
Randomized comparison of amodiaquine plus sulfadoxine-pyrimethamine, artemether-lumefantrine, and dihydroartemisinin-piperaquine for the treatment of uncomplicated Plasmodium falciparum malaria in…
BACKGROUND Combination antimalarial therapy is advocated to improve treatment efficacy and limit selection of drug-resistant… 
Review
2006
Review
2006
Drugs for preventing malaria in pregnant women.
BACKGROUND Malaria contributes to maternal illness and anaemia in pregnancy, especially in first-time mothers, and can harm the… 
Review
2004
Review
2004
The origins of antimalarial drug resistance.
Review
2002
Review
2002
The evolution of drug-resistant malaria: the role of drug elimination half-life.
This paper seeks to define and quantify the influence of drug elimination half-life on the evolution of antimalarial drug… 
Highly Cited
2000
Highly Cited
2000
Molecular evidence of greater selective pressure for drug resistance exerted by the long-acting antifolate Pyrimethamine/Sulfadoxine compared with the shorter-acting chlorproguanil/dapsone on Kenyan…
Pyrimethamine (PM) plus sulfadoxine (SD) is the last remaining affordable drug for treating uncomplicated malaria in Africa. The… 
Highly Cited
1999
Highly Cited
1999
Increased prevalence of malaria in HIV‐infected pregnant women and its implications for malaria control
Summary objectives  To examine in pregnant women the relationship between HIV infection and malaria prevalence and to determine… 
Highly Cited
1998
Highly Cited
1998
Cycloguanil and its parent compound proguanil demonstrate distinct activities against Plasmodium falciparum malaria parasites transformed with human dihydrofolate reductase.
The lack of suitable antimalarial agents to replace chloroquine and pyrimethamine/sulfadoxine threatens efforts to control the… 
Review
1994
Review
1994
Epidemiology of drug resistance in malaria.
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