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Combination therapies exploit the chances for better efficacy, decreased toxicity, and reduced development of drug resistance and… Expand Targeted cancer therapies have produced substantial clinical responses, but most tumors develop resistance to these drugs. Here… Expand This brief perspective article focuses on the most common errors and pitfalls, as well as the do's and don'ts in drug combination… Expand Two or more antihypertensive agents are increasingly used to control blood pressure (BP) in hypertensive patients. However, it is… Expand Drug combinations are a promising strategy to overcome the compensatory mechanisms and unwanted off-target effects that limit the… Expand Nature Reviews Drug Discovery 8, 111–128 (2009) | 10.1038/nrd2683 There are two errors in the author names: Zhiwei W. Cao should… Expand Drugs designed to act against individual molecular targets cannot usually combat multigenic diseases such as cancer, or diseases… Expand The median-effect equation derived from the mass-action law principle at equilibrium-steady state via mathematical induction and… Expand In evaluating current combination drug regimens for treatment of human immunodeficiency virus (HIV) disease, it is important to… Expand BACKGROUND
The combination of streptozocin and fluorouracil has become the standard therapy for advanced islet-cell carcinoma… Expand