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Drug Combinations

Known as: Combinations, Drug, combination drug, drug combination 
Single preparations containing two or more active agents, for the purpose of their concurrent administration as a fixed dose mixture.
National Institutes of Health

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Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2015
Review
2015
Analysis of drug combinations: current methodological landscape
Combination therapies exploit the chances for better efficacy, decreased toxicity, and reduced development of drug resistance and… Expand
Highly Cited
2014
Highly Cited
2014
Patient-derived models of acquired resistance can identify effective drug combinations for cancer
Targeted cancer therapies have produced substantial clinical responses, but most tumors develop resistance to these drugs. Here… Expand
Highly Cited
2010
Highly Cited
2010
Drug combination studies and their synergy quantification using the Chou-Talalay method.
  • T. Chou
  • Cancer research
  • 2010
    • Corpus ID: 1324495
This brief perspective article focuses on the most common errors and pitfalls, as well as the do's and don'ts in drug combination… Expand
Review
2010
Review
2010
Compliance, Safety, and Effectiveness of Fixed-Dose Combinations of Antihypertensive Agents: A Meta-Analysis
Two or more antihypertensive agents are increasingly used to control blood pressure (BP) in hypertensive patients. However, it is… Expand
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Highly Cited
2009
Highly Cited
2009
Synergistic drug combinations improve therapeutic selectivity
Drug combinations are a promising strategy to overcome the compensatory mechanisms and unwanted off-target effects that limit the… Expand
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Review
2009
Review
2009
Mechanisms of drug combinations: interaction and network perspectives
Nature Reviews Drug Discovery 8, 111–128 (2009) | 10.1038/nrd2683 There are two errors in the author names: Zhiwei W. Cao should… Expand
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Review
2007
Review
2007
Multi-target therapeutics: when the whole is greater than the sum of the parts.
Drugs designed to act against individual molecular targets cannot usually combat multigenic diseases such as cancer, or diseases… Expand
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Review
2006
Review
2006
Theoretical Basis, Experimental Design, and Computerized Simulation of Synergism and Antagonism in Drug Combination Studies
  • T. Chou
  • Pharmacological Reviews
  • 2006
    • Corpus ID: 7055257
The median-effect equation derived from the mass-action law principle at equilibrium-steady state via mathematical induction and… Expand
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Highly Cited
1997
Highly Cited
1997
Recovery of replication-competent HIV despite prolonged suppression of plasma viremia.
In evaluating current combination drug regimens for treatment of human immunodeficiency virus (HIV) disease, it is important to… Expand
Highly Cited
1992
Highly Cited
1992
Streptozocin-doxorubicin, streptozocin-fluorouracil or chlorozotocin in the treatment of advanced islet-cell carcinoma.
BACKGROUND The combination of streptozocin and fluorouracil has become the standard therapy for advanced islet-cell carcinoma… Expand
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