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Drug Combinations
Known as:
Combinations, Drug
, combination drug
, drug combination
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Single preparations containing two or more active agents, for the purpose of their concurrent administration as a fixed dose mixture.
National Institutes of Health
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Angiosan
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Donnatal
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Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Review
2015
Review
2015
Analysis of drug combinations: current methodological landscape
J. Foucquier
,
M. Guedj
Pharmacology research & perspectives
2015
Corpus ID: 13416155
Combination therapies exploit the chances for better efficacy, decreased toxicity, and reduced development of drug resistance and…
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Highly Cited
2014
Highly Cited
2014
Patient-derived models of acquired resistance can identify effective drug combinations for cancer
A. Crystal
,
A. Shaw
,
+23 authors
J. Engelman
Science
2014
Corpus ID: 31228812
Targeted cancer therapies have produced substantial clinical responses, but most tumors develop resistance to these drugs. Here…
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Highly Cited
2010
Highly Cited
2010
Drug combination studies and their synergy quantification using the Chou-Talalay method.
T. Chou
Cancer research
2010
Corpus ID: 1324495
This brief perspective article focuses on the most common errors and pitfalls, as well as the do's and don'ts in drug combination…
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Review
2010
Review
2010
Compliance, Safety, and Effectiveness of Fixed-Dose Combinations of Antihypertensive Agents: A Meta-Analysis
Ajay K. Gupta
,
S. Arshad
,
N. Poulter
Hypertension
2010
Corpus ID: 8398677
Two or more antihypertensive agents are increasingly used to control blood pressure (BP) in hypertensive patients. However, it is…
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Highly Cited
2009
Highly Cited
2009
Synergistic drug combinations improve therapeutic selectivity
J. Lehár
,
A. Krueger
,
+10 authors
A. Borisy
Nature Biotechnology
2009
Corpus ID: 17954263
Drug combinations are a promising strategy to overcome the compensatory mechanisms and unwanted off-target effects that limit the…
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Review
2007
Review
2007
Multi-target therapeutics: when the whole is greater than the sum of the parts.
G. Zimmermann
,
J. Lehár
,
C. Keith
Drug discovery today
2007
Corpus ID: 28766172
Review
2006
Review
2006
Theoretical Basis, Experimental Design, and Computerized Simulation of Synergism and Antagonism in Drug Combination Studies
T. Chou
Pharmacological Reviews
2006
Corpus ID: 7055257
The median-effect equation derived from the mass-action law principle at equilibrium-steady state via mathematical induction and…
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Highly Cited
2004
Highly Cited
2004
Rational combinations of trastuzumab with chemotherapeutic drugs used in the treatment of breast cancer.
M. Pegram
,
G. Konecny
,
C. O'Callaghan
,
Malgorzata Beryt
,
R. Pietras
,
D. Slamon
Journal of the National Cancer Institute
2004
Corpus ID: 22409635
BACKGROUND Trastuzumab, a humanized anti-HER2 antibody, increases the clinical benefit of first-line chemotherapy in patients…
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Highly Cited
1997
Highly Cited
1997
Recovery of replication-competent HIV despite prolonged suppression of plasma viremia.
J. Wong
,
M. Hezareh
,
+4 authors
D. Richman
Science
1997
Corpus ID: 32126718
In evaluating current combination drug regimens for treatment of human immunodeficiency virus (HIV) disease, it is important to…
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Highly Cited
1992
Highly Cited
1992
Streptozocin-doxorubicin, streptozocin-fluorouracil or chlorozotocin in the treatment of advanced islet-cell carcinoma.
C. Moertel
,
M. Lefkopoulo
,
S. Lipsitz
,
R. Hahn
,
D. Klaassen
The New England journal of medicine
1992
Corpus ID: 10191582
BACKGROUND The combination of streptozocin and fluorouracil has become the standard therapy for advanced islet-cell carcinoma…
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