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In vivo cultivation of tumor cells in hollow fibers.
Results of experimentation to date demonstrate that a hollow fiber encapsulation/implantation methodology provides quantitative indices of drug efficacy with minimum expenditures of time and materials. Expand
Inhibitors of HIV Nucleocapsid Protein Zinc Fingers as Candidates for the Treatment of AIDS
Nontoxic disulfide-substituted benzamides were identified that attack the zinc fingers, inactivate cell-free virions, inhibit acute and chronic infections, and exhibit broad antiretroviral activity. Expand
Preclinical pharmacologic evaluation of geldanamycin as an antitumor agent
In consideration of the potential for acute hepatotoxic reactions to GM, as well as to the other benzoquinoid ansamycins based upon structural analogy, additional pharmacological and therapeutic information is required to ascertain whether these compounds are viable candidates for clinical development. Expand
Halichondrin B and homohalichondrin B, marine natural products binding in the vinca domain of tubulin. Discovery of tubulin-based mechanism of action by analysis of differential cytotoxicity data.
Halichondrin B was compared with other agents which interfere with the binding of vinca alkaloids to tubulin in terms of its effects on tubulin polymerization, inhibition of GTP hydrolysis, inhibited of nucleotide exchange, and stabilization of tubulin, as well as the quantitative assessment of its effect on vincA alkaloid binding and inhibition of cell growth. Expand
Pharmacokinetics of 2-F-ara-A (9-beta-D-arabinofuranosyl-2-fluoroadenine) in cancer patients during the phase I clinical investigation of fludarabine phosphate.
Total-body clearance and the volume parameters Vdss and Vd gamma decreased with an increase in serum creatinine, indicating that these pharmacokinetic parameters depend upon renal function and Dose reduction in patients with renal dysfunction is recommended. Expand
Growth and chemotherapeutic response of cells in a hollow-fiber in vitro solid tumor model.
The successful growth of tumor cells to confluence in hollow fibers and the feasibility of performing in vitro drug dose-response experiments with a relatively easy colorimetric assay demonstrate the potential of the hollow-fiber solid tumor model as a tool for experimental therapeutic research. Expand
Concomitant adsorption and stability of some anthracycline antibiotics.
Both the adsorption and stability effects are suggested as being factors which should be carefully considered in interpretation of the in vitro and perhaps in vivo activities of the anthracycline esters. Expand
Identification of novel antimitotic agents acting at the tubulin level by computer-assisted evaluation of differential cytotoxicity data.
Data generated in the new National Cancer Institute drug evaluation program, which are based on inhibition of cell growth in 60 human tumor cell lines, were probed with nine known antimitotic agents using the COMPARE algorithm to have great promise for the identification of new antimitosis agents with antineoplastic potential. Expand
Jasplakinolide's inhibition of the growth of prostate carcinoma cells in vitro with disruption of the actin cytoskeleton.
Jasplakinolide represents a novel marine natural product with potent in vitro antiproliferative activity against human prostate carcinoma cell lines, and it appears to target the actin cytoskeleton. Expand
A Reversed-Phase HPLC Method For Determining Camptothecin In Plasma With Specificity For the Intact Lactone Form of the Drug
Abstract Camptothecin is a pentacyclic indole alkaloid with a terminal α-hydroxy-δ-lactone ring, which in aqueous media at physiological pH, exists in equilibrium with the dissociated open-lactoneExpand