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Selection of Plasmodium falciparum pfmdr1 Alleles following Therapy with Artemether-Lumefantrine in an Area of Uganda where Malaria Is Highly Endemic
ABSTRACT Polymorphisms in the Plasmodium falciparum pfmdr1 gene were assayed in pretreatment samples and in samples from patients reinfected following therapy with artemether-lumefantrine. The pfmdr1Expand
Polymorphisms in Plasmodium falciparum Chloroquine Resistance Transporter and Multidrug Resistance 1 Genes: Parasite Risk Factors that Affect Treatment Outcomes for P. falciparum Malaria after
Monitoring selection and responding to emerging signs of drug resistance are critical tools for preserving efficacy of artemisinin combination therapies; determination of the prevalence of at least pfcrt K76T and pfmdr1 N86Y should now be routine. Expand
Polymorphisms in K13 and Falcipain-2 Associated with Artemisinin Resistance Are Not Prevalent in Plasmodium falciparum Isolated from Ugandan Children
The prevalence of K13-propeller and FP2 polymorphisms did not increase over time, and was not associated with either time since prior receipt of an ACT or the persistence of parasites ≥2 days following treatment with an ACT, indicating that artemisinin resistance is not prevalent in Uganda. Expand
Artemether-Lumefantrine versus Dihydroartemisinin-Piperaquine for Treatment of Malaria: A Randomized Trial
DP was superior to AL for reducing the risk of recurrent parasitemia and gametocytemia, and provided improved hemoglobin recovery, and appears to be a good alternative to AL as first-line treatment of uncomplicated malaria in Uganda. Expand
Artemether-Lumefantrine versus Dihydroartemisinin-Piperaquine for Treating Uncomplicated Malaria: A Randomized Trial to Guide Policy in Uganda
Dihydroartemisinin-piperaquine is highly efficacious, and operationally preferable to AL because of a less intensive dosing schedule and requirements and should be considered for a role in the antimalarial treatment policy of Uganda. Expand
FCRL5 Delineates Functionally Impaired Memory B Cells Associated with Plasmodium falciparum Exposure
FCLR5+ identifies a functionally distinct, and perhaps dysfunctional, subset of MBCs in individuals exposed to P. falciparum, which is similar to dysfunctional B cells found in HIV-infected individuals. Expand
Polymorphisms in the Plasmodium falciparum pfcrt and pfmdr-1 genes and clinical response to chloroquine in Kampala, Uganda.
In evaluations of known polymorphisms in parasites from patients with uncomplicated malaria in Kampala, Uganda, the presence of 8 pfcrt mutations and 2 pfmdr-1 mutations did not correlate with clinical response to therapy with chloroquine, suggesting that other factors may contribute to clinical outcomes. Expand
In vivo parasitological measures of artemisinin susceptibility.
Clearance rates were faster in high-transmission settings and with more effective partner drugs in artemisinin-based combination treatments (ACTs) and Artemisinin resistance is highly unlikely if the proportion of patients with parasite densities of <100,000 parasites/microL given the currently recommended 3-day ACT who have a positive smear result on day 3 is <3%. Expand
Malaria in Uganda: challenges to control on the long road to elimination: I. Epidemiology and current control efforts.
There is no convincing evidence that the burden of malaria has decreased in Uganda in recent years, and major challenges to malaria control include very high malaria transmission intensity, inadequate health care resources, a weak health system, inadequate understanding of malaria epidemiology and the impact of control interventions, and inadequate epidemic preparedness and response. Expand
Uganda Demographic and Health Survey 2016. Key indicators report.
The 2016 UDHS collected information on fertility levels marriage sexual activity fertility preferences breastfeeding practices and awareness and use of family planning methods which generated other indicators relevant to the Health Sector Strategic and Investment Plan (HSSP III) the National Development Plan II (NDP II) and the Sustainable Development Goals (SDGs). Expand