Control of Regulatory T Cell Development by the Transcription Factor Foxp3
Foxp3, which encodes a transcription factor that is genetically defective in an autoimmune and inflammatory syndrome in humans and mice, is specifically expressed in naturally arising CD4+ regulatory T cells and retroviral gene transfer of Foxp3 converts naïve T cells toward a regulatory T cell phenotype similar to that of naturally occurring CD4+.
Regulatory T Cells and Immune Tolerance
CTLA-4 Control over Foxp3+ Regulatory T Cell Function
It is shown that a specific deficiency of cytotoxic T lymphocyte antigen 4 (CTLA-4) in Tregs results in spontaneous development of systemic lymphoproliferation, fatal T cell–mediated autoimmune disease, and hyperproduction of immunoglobulin E in mice.
Functional delineation and differentiation dynamics of human CD4+ T cells expressing the FoxP3 transcription factor.
Mutations in the P. falciparum digestive vacuole transmembrane protein PfCRT and evidence for their role in chloroquine resistance.
Preferential recruitment of CCR6-expressing Th17 cells to inflamed joints via CCL20 in rheumatoid arthritis and its animal model
- K. Hirota, H. Yoshitomi, S. Sakaguchi
- Biology, MedicineJournal of Experimental Medicine
- 26 November 2007
The results indicate that CCR6 expression contributes to Th17 cell function in autoimmune disease, especially in autoimmune arthritis such as RA.
Foxp3+CD25+CD4+ natural regulatory T cells in dominant self‐tolerance and autoimmune disease
Elucidation of the molecular and cellular basis of this Treg‐mediated active maintenance of self‐tolerance will facilitate both the understanding of the pathogenetic mechanism of autoimmune disease and the development of novel methods of autoimmunity prevention and treatment via enhancing and re‐establishing T Reg‐mediated dominant control over self‐reactive T cells.
Foxp3 controls regulatory T-cell function by interacting with AML1/Runx1
It is shown that the transcription factor AML1 (acute myeloid leukaemia 1)/Runx1 (Runt-related transcription factor 1), which is crucially required for normal haematopoiesis including thymic T-cell development, activates IL-2 and IFN-γ gene expression in conventional CD4+ T cells through binding to their respective promoters.
Crucial role of FOXP3 in the development and function of human CD25+CD4+ regulatory T cells.
FoxP3 is a crucial regulatory gene for the development and function of CD25(+)CD4(+) regulatory T cells, and can be used as their reliable marker for treatment of autoimmune/inflammatory diseases and negative control of various immune responses.
Altered thymic T-cell selection due to a mutation of the ZAP-70 gene causes autoimmune arthritis in mice
It is shown that a spontaneous point mutation of the gene encoding an SH2 domain of ZAP-70, a key signal transduction molecule in T cells, causes chronic autoimmune arthritis in mice that resembles human RA in many aspects.