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- Publications
- Influence
Mutations in the P. falciparum digestive vacuole transmembrane protein PfCRT and evidence for their role in chloroquine resistance.
- D. Fidock, T. Nomura, +11 authors T. Wellems
- Biology, Medicine
- Molecular cell
- 1 October 2000
The determinant of verapamil-reversible chloroquine resistance (CQR) in a Plasmodium falciparum genetic cross maps to a 36 kb segment of chromosome 7. This segment harbors a 13-exon gene, pfcrt,… Expand
Antimalarial drug discovery: efficacy models for compound screening
- D. Fidock, P. Rosenthal, S. Croft, R. Brun, Solomon Nwaka
- Biology, Medicine
- Nature Reviews Drug Discovery
- 1 June 2004
Increased efforts in antimalarial drug discovery are urgently needed. The goal must be to develop safe and affordable new drugs to counter the spread of malaria parasites that are resistant to… Expand
Malaria: progress, perils, and prospects for eradication.
- B. Greenwood, D. Fidock, +4 authors P. Duffy
- Biology, Medicine
- The Journal of clinical investigation
- 1 April 2008
There are still approximately 500 million cases of malaria and 1 million deaths from malaria each year. Yet recently, malaria incidence has been dramatically reduced in some parts of Africa by… Expand
Transformation with human dihydrofolate reductase renders malaria parasites insensitive to WR99210 but does not affect the intrinsic activity of proguanil.
- D. Fidock, T. Wellems
- Biology, Medicine
- Proceedings of the National Academy of Sciences…
- 30 September 1997
Increasing resistance of Plasmodium falciparum malaria parasites to chloroquine and the dihydrofolate reductase (DHFR) inhibitors pyrimethamine and cycloguanil have sparked renewed interest in the… Expand
Chloroquine Resistance in Plasmodium falciparum Malaria Parasites Conferred by pfcrt Mutations
- A. Sidhu, D. Verdier-Pinard, D. Fidock
- Biology, Medicine
- Science
- 4 October 2002
Plasmodium falciparum chloroquine resistance is a major cause of worldwide increases in malaria mortality and morbidity. Recent laboratory and clinical studies have associated chloroquine resistance… Expand
A Worldwide Map of Plasmodium falciparum K13-Propeller Polymorphisms.
- Didier Ménard, Nimol Khim, +86 authors O. Mercereau-Puijalon
- Biology, Medicine
- The New England journal of medicine
- 22 June 2016
BACKGROUND
Recent gains in reducing the global burden of malaria are threatened by the emergence of Plasmodium falciparum resistance to artemisinins. The discovery that mutations in portions of a P.… Expand
K13-propeller mutations confer artemisinin resistance in Plasmodium falciparum clinical isolates
- J. Straimer, Nina F Gnädig, +14 authors D. Fidock
- Biology, Medicine
- Science
- 23 January 2015
Mechanisms propelling drug resistance If it were to spread, resistance to the drug artemisinin would seriously derail the recent gains of global malaria control programs (see the Perspective by… Expand
pfmdr1 mutations contribute to quinine resistance and enhance mefloquine and artemisinin sensitivity in Plasmodium falciparum
- A. Sidhu, S. Valderramos, D. Fidock
- Biology, Medicine
- Molecular microbiology
- 1 August 2005
The emergence and spread of multidrug resistant Plasmodium falciparum has severely limited the therapeutic options for the treatment of malaria. With ever‐increasing failure rates associated with… Expand
Quantitative assessment of Plasmodium falciparum sexual development reveals potent transmission-blocking activity by methylene blue
- Sophie H. Adjalley, Geoffrey L. Johnston, +8 authors D. Fidock
- Biology, Medicine
- Proceedings of the National Academy of Sciences
- 31 October 2011
Clinical studies and mathematical models predict that, to achieve malaria elimination, combination therapies will need to incorporate drugs that block the transmission of Plasmodium falciparum sexual… Expand
Efficient site-specific integration in Plasmodium falciparum chromosomes mediated by mycobacteriophage Bxb1 integrase
- Louis J Nkrumah, R. Muhle, +4 authors D. Fidock
- Biology, Medicine
- Nature Methods
- 1 August 2006
Here we report an efficient, site-specific system of genetic integration into Plasmodium falciparum malaria parasite chromosomes. This is mediated by mycobacteriophage Bxb1 integrase, which catalyzes… Expand