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Pyrimethamine

Known as: 5-(4-Chlorophenyl)-6-ethyl-2,4-diaminopyrimidine, CD, Primethamine 
A synthetic derivative of ethyl-pyrimidine with potent antimalarial properties. Pyrimethamine is a competitive inhibitor of dihydrofolate reductase… 
National Institutes of Health

Related topics

Related topics

40 relations

Narrower (19)

3-azidopyrimethamineCC 83ChloridinChloridine
AIDS-Related Opportunistic InfectionsAnemia, PerniciousDapsone / PyrimethamineDrug Allergy

Broader (5)

AntimalarialsAntiprotozoal AgentsFolic Acid AntagonistsPyrimidine

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2009
2009
Plasma half-lives and the excretion into egg-white and -yolk of three sulponamides and pyrimethamine after medication of laying hens.
: The concentration of drugs in blood plasma and the excretion into egg-white and -yolk were studied after continuous… 
2006
2006
Cadmium-induced stimulation of stress-protein hsp70 in lichen photobiont Trebouxia erici
The expression of stress protein 70 (hsp70) was studied in lichen photobiont Trebouxia erici during short-term exposition to… 
1995
1995
Transport of inorganic phosphate in renal cortical brush-border membrane vesicles of cadmium-intoxicated rats.
The effect of cadmium intoxication on the renal proximal tubular phosphate transport system was studied in adult male Sprague… 
1986
1986
Age-related dose response of selected reproductive parameters to acute cadmium chloride exposure in the male Long-Evans rat.
Groups of male Long-Evans rats 30, 50, or 70 d old were injected subcutaneously (sc) with a single dose of 0, 5.5, 11.5, or 24.6… 
1984
1984
The effect of low doses of dietary cadmium oxide on the disposition of trace elements (zinc, copper, iron), hematological parameters, and liver function in rats
The Zn, Cu, and Fe concentrations in selected organs, tissues and in the excreta of male Wistar rats, exposed to dietary CdO (2… 
1981
1981
Cadmium, copper, and zinc distribution in blood of rats after long-term cadmium administration.
Cd, Cu, and Zn were determined in plasma and blood cells of rats given daily sc injections of 0.5 mg Cd per kilogram of body… 
Highly Cited
1980
Highly Cited
1980
Pyrimethamine sensitivity in Plasmodium falciparum: determination in vitro by a modified 48-hour test.
Four strains of Plasmodium falciparum recently isolated in culture were assessed in vitro for their response to pyrimethamine. A… 
1976
1976
Tolerance development to cadmium-induced alteration of drug action.
Cadmium administration potentiates the duration of hexobarbital-induced hypnosis and inhibits the rate of hepatic microsomal… 
1970
1970
Spectra of susceptibility of Neisseria meningitidis to antimicrobial agents in vitro.
The minimal inhibitory concentrations of 49 antimicrobial agents for 37 to 40 meningococcal strains freshly isolated from the… 
1956
1956
Treatment of toxoplasmosis with pyrimethamine (daraprim) and triple sulfonamide.
Excerpt In the short space of 16 years since toxoplasmosis was first recognized as a disease in human beings, great strides have…