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Pyrimethamine

Known as: 5-(4-Chlorophenyl)-6-ethyl-2,4-diaminopyrimidine, CD, Primethamine 
A synthetic derivative of ethyl-pyrimidine with potent antimalarial properties. Pyrimethamine is a competitive inhibitor of dihydrofolate reductase… Expand
National Institutes of Health

Papers overview

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Review
2018
Review
2018
Toxoplasma gondii (T. gondii) is a global protozoan parasite infecting up to one-third of the world population. Pyrimethamine… Expand
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Review
2016
Review
2016
The protozoan Toxoplasma gondii, an obligate intracellular parasite, is an etiological agent of human and animal toxoplasmosis… Expand
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Review
2009
Review
2009
Cadmium is a toxic metal occurring in the environment naturally and as a pollutant emanating from industrial and agricultural… Expand
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Highly Cited
2004
Highly Cited
2004
Here we present molecular evidence demonstrating that malaria parasites bearing high-level pyrimethamine resistance originally… Expand
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Highly Cited
2003
Highly Cited
2003
Malaria parasites (Plasmodium falciparum) provide an excellent system in which to study the genomic effects of strong selection… Expand
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Highly Cited
1997
Highly Cited
1997
When little or no data directly comparing two treatments are available, investigators often rely on indirect comparisons from… Expand
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Highly Cited
1992
Highly Cited
1992
OBJECTIVE To compare pyrimethamine plus clindamycin (PC) to pyrimethamine plus sulfadiazine (PS) as a treatment for toxoplasmic… Expand
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Highly Cited
1990
Highly Cited
1990
Proguanil and pyrimethamine are antifolate drugs with distinct chemical structures that are used commonly in the prophylaxis and… Expand
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Highly Cited
1988
Highly Cited
1988
Analysis of a genetic cross of Plasmodium falciparum and of independent parasite isolates from Southeast Asia, Africa, and South… Expand
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Highly Cited
1988
Highly Cited
1988
We describe the isolation and the sequence of the gene for the bifunctional enzyme dihydrofolate reductase-thymidylate synthase… Expand
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