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Pyrimethamine

Known as: 5-(4-Chlorophenyl)-6-ethyl-2,4-diaminopyrimidine, CD, Primethamine 
A synthetic derivative of ethyl-pyrimidine with potent antimalarial properties. Pyrimethamine is a competitive inhibitor of dihydrofolate reductase… 
National Institutes of Health

Related topics

Related topics

40 relations

Narrower (19)

3-azidopyrimethamineCC 83ChloridinChloridine
AIDS-Related Opportunistic InfectionsAnemia, PerniciousDapsone / PyrimethamineDrug Allergy

Broader (5)

AntimalarialsAntiprotozoal AgentsFolic Acid AntagonistsPyrimidine

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2007
Review
2007
Safety and Toxicity of Sulfadoxine/Pyrimethamine
Plasmodium falciparum infection during pregnancy is strongly associated with maternal anaemia and low birth weight, contributing… 
Highly Cited
2006
Highly Cited
2006
Environmental contamination of heavy metals from zinc smelting areas in Hezhang County, western Guizhou, China.
Highly Cited
2006
Highly Cited
2006
Transfer characteristics of cadmium and lead from soil to the edible parts of six vegetable species in southeastern China.
Highly Cited
2004
Highly Cited
2004
Heavy metal accumulation by two earthworm species and its relationship to total and DTPA-extractable metals in soils
Highly Cited
2001
Highly Cited
2001
Use of diammonium phosphate to reduce heavy metal solubility and transport in smelter-contaminated soil.
Phosphate treatments can reduce metal dissolution and transport from contaminated soils. However, diammonium phosphate (DAP) has… 
Highly Cited
2000
Highly Cited
2000
The inhibitory effect of zinc on cadmium-induced cell apoptosis and reactive oxygen species (ROS) production in cell cultures.
Highly Cited
1998
Highly Cited
1998
Cadmium toxicity effects on growth, mineral and chlorophyll contents, and activities of stress related enzymes in young maize plants (Zea mays L.)
Plants were cultivated in a nutrient solution containing increasing cadmium concentrations (i.e. 0.001–25 µM), under strictly… 
Highly Cited
1996
Highly Cited
1996
Transformation of Plasmodium falciparum malaria parasites by homologous integration of plasmids that confer resistance to pyrimethamine.
Plasmodium falciparum malaria parasites were transformed with plasmids containing P. falciparum or Toxoplasma gondii… 
Highly Cited
1990
Highly Cited
1990
Molecular basis of differential resistance to cycloguanil and pyrimethamine in Plasmodium falciparum malaria.
Proguanil and pyrimethamine are antifolate drugs with distinct chemical structures that are used commonly in the prophylaxis and… 
Highly Cited
1976
Highly Cited
1976
A mechanism for cadmium- and zinc-induced tolerance to cadmium toxicity: involvement of metallothionein.
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