Pyrimethamine

Known as: 5-(4-Chlorophenyl)-6-ethyl-2,4-diaminopyrimidine, CD, Primethamine 
A synthetic derivative of ethyl-pyrimidine with potent antimalarial properties. Pyrimethamine is a competitive inhibitor of dihydrofolate reductase… (More)
National Institutes of Health

Papers overview

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Highly Cited
2009
Highly Cited
2009
The spread of high-level pyrimethamine resistance in Africa threatens to curtail the therapeutic lifetime of antifolate… (More)
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Review
2009
Review
2009
Cadmium is a toxic metal occurring in the environment naturally and as a pollutant emanating from industrial and agricultural… (More)
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Highly Cited
2004
Highly Cited
2004
Here we present molecular evidence demonstrating that malaria parasites bearing high-level pyrimethamine resistance originally… (More)
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Highly Cited
2003
Highly Cited
2003
Malaria parasites (Plasmodium falciparum) provide an excellent system in which to study the genomic effects of strong selection… (More)
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Highly Cited
1997
Highly Cited
1997
When little or no data directly comparing two treatments are available, investigators often rely on indirect comparisons from… (More)
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Highly Cited
1996
Highly Cited
1996
Plasmodium falciparum malaria parasites were transformed with plasmids containing P. falciparum or Toxoplasma gondii… (More)
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Highly Cited
1990
Highly Cited
1990
Proguanil and pyrimethamine are antifolate drugs with distinct chemical structures that are used commonly in the prophylaxis and… (More)
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Highly Cited
1990
Highly Cited
1990
Cycloguanil, the active metabolite of the antimalarial drug proguanil, is an inhibitor of dihydrofolate reductase as is another… (More)
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Highly Cited
1988
Highly Cited
1988
Analysis of a genetic cross of Plasmodium falciparum and of independent parasite isolates from Southeast Asia, Africa, and South… (More)
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Highly Cited
1988
Highly Cited
1988
We describe the isolation and the sequence of the gene for the bifunctional enzyme dihydrofolate reductase-thymidylate synthase… (More)
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