Skip to search formSkip to main contentSkip to account menu

Folic Acid Antagonists

Known as: Folate Analog, Antifolates, Antagonists, Folic Acid 
Inhibitors of the enzyme, dihydrofolate reductase (TETRAHYDROFOLATE DEHYDROGENASE), which converts dihydrofolate (FH2) to tetrahydrofolate (FH4… 
National Institutes of Health

Related topics

Related topics

46 relations

Narrower (37)

10-deazaaminopterin1843U893',5'-dichloromethotrexate3'-fluoroaminopterin
Expand
AntimetabolitesAntimetabolites, AntineoplasticDihydrofolate Reductase InhibitorsFolic acid analogs, antimetabolites
Expand

Broader (1)

vitamin antagonist

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2009
Highly Cited
2009
Maintenance pemetrexed plus best supportive care versus placebo plus best supportive care for non-small-cell lung cancer: a randomised, double-blind, phase 3 study
Review
2005
Review
2005
Chemotherapy and the war on cancer
The era of chemotherapy began in the 1940s with the first uses of nitrogen mustards and antifolate drugs. Cancer drug development… 
Highly Cited
2001
Highly Cited
2001
Folic acid antagonists during pregnancy and risk of birth defects.
A BSTRACT Background Multivitamin supplementation in pregnant women may reduce the risks of cardiovascular defects, oral clefts… 
Highly Cited
2000
Highly Cited
2000
Folic acid antagonists during pregnancy and the risk of birth defects.
Background Multivitamin supplementation in pregnant women may reduce the risks of cardiovascular defects, oral clefts, and… 
Highly Cited
1994
Highly Cited
1994
Differential regulation of folate receptor isoforms in normal and malignant tissues in vivo and in established cell lines. Physiologic and clinical implications
Background. Despite significant differences in ligand binding between the two known isoforms of the human membrane folate… 
Review
1994
Review
1994
Supplementation with Folic Acid during Methotrexate Therapy for Rheumatoid Arthritis: A Double-Blind, Placebo-Controlled Trial
The folic acid antagonist methotrexate (n-10-methyl-aminopterin) is useful in low doses (2.5 to 20 mg/wk) for treating chronic… 
Highly Cited
1993
Highly Cited
1993
The antiinflammatory mechanism of methotrexate. Increased adenosine release at inflamed sites diminishes leukocyte accumulation in an in vivo model of inflammation.
Methotrexate, a folate antagonist, is a potent antiinflammatory agent when used weekly in low concentrations. We examined the… 
Highly Cited
1988
Highly Cited
1988
Evidence that a point mutation in dihydrofolate reductase-thymidylate synthase confers resistance to pyrimethamine in falciparum malaria.
Analysis of a genetic cross of Plasmodium falciparum and of independent parasite isolates from Southeast Asia, Africa, and South… 
Highly Cited
1986
Highly Cited
1986
Binding of a specific ligand inhibits import of a purified precursor protein into mitochondria
Methotrexate, a folate antagonist, blocks import into mitochondria of mouse dihydrofolate reductase fused to a mitochondrial… 
Highly Cited
1948
Highly Cited
1948
Temporary remissions in acute leukemia in children produced by folic acid antagonist, 4-aminopteroyl-glutamic acid.
IT IS the purpose of this paper to record the results of clinical and hematologic studies on 5 children with acute leukemia… 
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy, Terms of Service, and Dataset License