Folic Acid Antagonists

Known as: Folate Analog, Antifolates, Antagonists, Folic Acid 
Inhibitors of the enzyme, dihydrofolate reductase (TETRAHYDROFOLATE DEHYDROGENASE), which converts dihydrofolate (FH2) to tetrahydrofolate (FH4… (More)
National Institutes of Health

Papers overview

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Highly Cited
2009
Highly Cited
2009
BACKGROUND Several studies have shown the efficacy, tolerability, and ease of administration of pemetrexed-an antifolate… (More)
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Highly Cited
2008
Highly Cited
2008
Fortification of food with folic acid to reduce the number of neural tube defects was introduced 10 y ago in North America. Many… (More)
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Highly Cited
2005
Highly Cited
2005
PURPOSE We conducted a phase III trial to determine whether first-line treatment with raltitrexed, a thymidine synthase inhibitor… (More)
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Highly Cited
2002
Highly Cited
2002
Molecular assays for monitoring sulfadoxine-pyrimethamine-resistant Plasmodium falciparum have not been implemented because of… (More)
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Highly Cited
2001
Highly Cited
2001
Periconceptional folic acid supplementation reduces the risk of neural tube defects (NTDs). To determine whether periconceptional… (More)
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Highly Cited
2000
Highly Cited
2000
  • ONIA, ERNÁNDEZ, +9 authors ITCHELL
  • 2000
A BSTRACT Background Multivitamin supplementation in pregnant women may reduce the risks of cardiovascular defects, oral clefts… (More)
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Highly Cited
1994
Highly Cited
1994
BACKGROUND Despite significant differences in ligand binding between the two known isoforms of the human membrane folate receptor… (More)
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Highly Cited
1988
Highly Cited
1988
Analysis of a genetic cross of Plasmodium falciparum and of independent parasite isolates from Southeast Asia, Africa, and South… (More)
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Highly Cited
1988
Highly Cited
1988
We describe the isolation and the sequence of the gene for the bifunctional enzyme dihydrofolate reductase-thymidylate synthase… (More)
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