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Folic Acid Antagonists

Known as: Folate Analog, Antifolates, Antagonists, Folic Acid 
Inhibitors of the enzyme, dihydrofolate reductase (TETRAHYDROFOLATE DEHYDROGENASE), which converts dihydrofolate (FH2) to tetrahydrofolate (FH4… 
National Institutes of Health

Related topics

Related topics

46 relations

Narrower (37)

10-deazaaminopterin1843U893',5'-dichloromethotrexate3'-fluoroaminopterin
AntimetabolitesAntimetabolites, AntineoplasticDihydrofolate Reductase InhibitorsFolic acid analogs, antimetabolites

Broader (1)

vitamin antagonist

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2004
Review
2004
Developing artemisinin based drug combinations for the treatment of drug resistant falciparum malaria: A review.
The emergence and spread of drug resistant malaria represents a considerable challenge to controlling malaria. To date, malaria… 
Highly Cited
2000
Highly Cited
2000
Methotrexate cross-resistance in a mitoxantrone-selected multidrug-resistant MCF7 breast cancer cell line is attributable to enhanced energy-dependent drug efflux.
Cellular resistance to the antifolate methotrexate (MTX) is often caused by target amplification, uptake defects, or alterations… 
Highly Cited
1988
Highly Cited
1988
Kinetics of the formation and isomerization of methotrexate complexes of recombinant human dihydrofolate reductase.
The kinetics of inhibitor binding to highly purified recombinant human dihydrofolate reductase (rHDHFR) have been examined… 
Highly Cited
1985
Highly Cited
1985
Gene amplification-associated cytogenetic aberrations and protein changes in vincristine-resistant Chinese hamster, mouse, and human cells
We carried out cytogenetic studies of four Chinese hamster, mouse, and human cell lines selected for high levels of resistance… 
Highly Cited
1984
Highly Cited
1984
Uptake and efficacy of trimetrexate (TMQ, 2,4-diamino-5-methyl-6-[(3,4,5-trimethoxyanilino)methyl] quinazoline), a non-classical antifolate in methotrexate-resistant leukemia cells in vitro.
Highly Cited
1984
Highly Cited
1984
Biochemical pharmacology of the lipophilic antifolate, trimetrexate.
Highly Cited
1983
Highly Cited
1983
Patterns of cross-resistance to the antifolate drugs trimetrexate, metoprine, homofolate, and CB3717 in human lymphoma and osteosarcoma cells resistant to methotrexate.
Methotrexate (MTX)-resistant sublines of malignant human cells were selected in vitro by stepwise increase in drug concentration… 
Highly Cited
1979
Highly Cited
1979
Characteristics of transport of 4-amino antifolates and folate compounds by two lines of L5178Y lymphoblasts, one with impaired transport of methotrexate.
In a line of L5178Y lymphoblasts resistant to methotrexate (MTX) by virtue of a permeability defect, there is a marked decrease… 
Highly Cited
1972
Highly Cited
1972
Two different species of dihydrofolate reductase in mammalian cells differentially resistant to amethopterin and methasquin.
The disparate cross-resistance behavior of certain amethopterin-resistant Chinese hamster cell lines to the quinazoline… 
Highly Cited
1968
Highly Cited
1968
Deranged DNA Synthesis by Bone Marrow from Vitamin B12‐Deficient Humans *
Summary. The synthesis of thymine DNA from deoxyuridine and uridine was studied by culturing human bone marrow for 1–3 hours in… 
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