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Folic Acid Antagonists

Known as: Folate Analog, Antifolates, Antagonists, Folic Acid 
Inhibitors of the enzyme, dihydrofolate reductase (TETRAHYDROFOLATE DEHYDROGENASE), which converts dihydrofolate (FH2) to tetrahydrofolate (FH4… Expand
National Institutes of Health

Papers overview

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Highly Cited
2009
Highly Cited
2009
BACKGROUND Several studies have shown the efficacy, tolerability, and ease of administration of pemetrexed-an antifolate… Expand
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Review
2005
Review
2005
The era of chemotherapy began in the 1940s with the first uses of nitrogen mustards and antifolate drugs. Cancer drug development… Expand
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Highly Cited
2001
Highly Cited
2001
A BSTRACT Background Multivitamin supplementation in pregnant women may reduce the risks of cardiovascular defects, oral clefts… Expand
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Highly Cited
2001
Highly Cited
2001
Periconceptional folic acid supplementation reduces the risk of neural tube defects (NTDs). To determine whether periconceptional… Expand
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Highly Cited
2000
Highly Cited
2000
Background Multivitamin supplementation in pregnant women may reduce the risks of cardiovascular defects, oral clefts, and… Expand
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Highly Cited
1997
Highly Cited
1997
N-[4-[2-(2-amino-3,4-dihydro-4-oxo-7H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl ]-benzoyl]-L-glutamic acid (LY231514) is a novel pyrrolo… Expand
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Highly Cited
1994
Highly Cited
1994
Background. Despite significant differences in ligand binding between the two known isoforms of the human membrane folate… Expand
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Highly Cited
1993
Highly Cited
1993
Methotrexate, a folate antagonist, is a potent antiinflammatory agent when used weekly in low concentrations. We examined the… Expand
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Highly Cited
1988
Highly Cited
1988
Analysis of a genetic cross of Plasmodium falciparum and of independent parasite isolates from Southeast Asia, Africa, and South… Expand
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Highly Cited
1948
Highly Cited
1948
IT IS the purpose of this paper to record the results of clinical and hematologic studies on 5 children with acute leukemia… Expand
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