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Folic Acid Antagonists

Known as: Folate Analog, Antifolates, Antagonists, Folic Acid 
Inhibitors of the enzyme, dihydrofolate reductase (TETRAHYDROFOLATE DEHYDROGENASE), which converts dihydrofolate (FH2) to tetrahydrofolate (FH4… Expand
National Institutes of Health

Related topics

Related topics

46 relations

Narrower (37)

10-deazaaminopterin1843U893',5'-dichloromethotrexate3'-fluoroaminopterin
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AntimetabolitesAntimetabolites, AntineoplasticDihydrofolate Reductase InhibitorsFolic acid analogs, antimetabolites
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Broader (1)

vitamin antagonist

Papers overview

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Highly Cited
2009
Highly Cited
2009
Maintenance pemetrexed plus best supportive care versus placebo plus best supportive care for non-small-cell lung cancer: a randomised, double-blind, phase 3 study
BACKGROUND Several studies have shown the efficacy, tolerability, and ease of administration of pemetrexed-an antifolate… Expand
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Review
2005
Review
2005
Chemotherapy and the war on cancer
The era of chemotherapy began in the 1940s with the first uses of nitrogen mustards and antifolate drugs. Cancer drug development… Expand
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Highly Cited
2001
Highly Cited
2001
Folic acid antagonists during pregnancy and risk of birth defects.
A BSTRACT Background Multivitamin supplementation in pregnant women may reduce the risks of cardiovascular defects, oral clefts… Expand
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Highly Cited
2001
Highly Cited
2001
Neural tube defects in relation to use of folic acid antagonists during pregnancy.
Periconceptional folic acid supplementation reduces the risk of neural tube defects (NTDs). To determine whether periconceptional… Expand
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Highly Cited
2000
Highly Cited
2000
Folic acid antagonists during pregnancy and the risk of birth defects.
Background Multivitamin supplementation in pregnant women may reduce the risks of cardiovascular defects, oral clefts, and… Expand
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Highly Cited
1997
Highly Cited
1997
LY231514, a pyrrolo[2,3-d]pyrimidine-based antifolate that inhibits multiple folate-requiring enzymes.
N-[4-[2-(2-amino-3,4-dihydro-4-oxo-7H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl ]-benzoyl]-L-glutamic acid (LY231514) is a novel pyrrolo… Expand
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Highly Cited
1994
Highly Cited
1994
Differential regulation of folate receptor isoforms in normal and malignant tissues in vivo and in established cell lines. Physiologic and clinical implications
Background. Despite significant differences in ligand binding between the two known isoforms of the human membrane folate… Expand
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Highly Cited
1993
Highly Cited
1993
The antiinflammatory mechanism of methotrexate. Increased adenosine release at inflamed sites diminishes leukocyte accumulation in an in vivo model of inflammation.
Methotrexate, a folate antagonist, is a potent antiinflammatory agent when used weekly in low concentrations. We examined the… Expand
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Highly Cited
1988
Highly Cited
1988
Evidence that a point mutation in dihydrofolate reductase-thymidylate synthase confers resistance to pyrimethamine in falciparum malaria.
Analysis of a genetic cross of Plasmodium falciparum and of independent parasite isolates from Southeast Asia, Africa, and South… Expand
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Highly Cited
1948
Highly Cited
1948
Temporary remissions in acute leukemia in children produced by folic acid antagonist, 4-aminopteroyl-glutamic acid.
IT IS the purpose of this paper to record the results of clinical and hematologic studies on 5 children with acute leukemia… Expand
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