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Folic Acid Antagonists

Known as: Folate Analog, Antifolates, Antagonists, Folic Acid 
Inhibitors of the enzyme, dihydrofolate reductase (TETRAHYDROFOLATE DEHYDROGENASE), which converts dihydrofolate (FH2) to tetrahydrofolate (FH4… 
National Institutes of Health

Papers overview

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Review
2005
Review
2005
The era of chemotherapy began in the 1940s with the first uses of nitrogen mustards and antifolate drugs. Cancer drug development… 
Highly Cited
2001
Highly Cited
2001
A BSTRACT Background Multivitamin supplementation in pregnant women may reduce the risks of cardiovascular defects, oral clefts… 
Highly Cited
2000
Highly Cited
2000
Background Multivitamin supplementation in pregnant women may reduce the risks of cardiovascular defects, oral clefts, and… 
Highly Cited
1994
Highly Cited
1994
Background. Despite significant differences in ligand binding between the two known isoforms of the human membrane folate… 
Review
1994
Review
1994
The folic acid antagonist methotrexate (n-10-methyl-aminopterin) is useful in low doses (2.5 to 20 mg/wk) for treating chronic… 
Highly Cited
1993
Highly Cited
1993
Methotrexate, a folate antagonist, is a potent antiinflammatory agent when used weekly in low concentrations. We examined the… 
Highly Cited
1988
Highly Cited
1988
Analysis of a genetic cross of Plasmodium falciparum and of independent parasite isolates from Southeast Asia, Africa, and South… 
Highly Cited
1986
Highly Cited
1986
Methotrexate, a folate antagonist, blocks import into mitochondria of mouse dihydrofolate reductase fused to a mitochondrial… 
Highly Cited
1948
Highly Cited
1948
IT IS the purpose of this paper to record the results of clinical and hematologic studies on 5 children with acute leukemia…