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Folic Acid Antagonists
Known as:
Folate Analog
, Antifolates
, Antagonists, Folic Acid
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Inhibitors of the enzyme, dihydrofolate reductase (TETRAHYDROFOLATE DEHYDROGENASE), which converts dihydrofolate (FH2) to tetrahydrofolate (FH4…
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National Institutes of Health
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Related topics
Related topics
46 relations
Narrower (37)
10-deazaaminopterin
1843U89
3',5'-dichloromethotrexate
3'-fluoroaminopterin
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Antimetabolites
Antimetabolites, Antineoplastic
Dihydrofolate Reductase Inhibitors
Folic acid analogs, antimetabolites
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Broader (1)
vitamin antagonist
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2009
Highly Cited
2009
Maintenance pemetrexed plus best supportive care versus placebo plus best supportive care for non-small-cell lung cancer: a randomised, double-blind, phase 3 study
T. Ciuleanu
,
T. Brodowicz
,
+16 authors
C. Belani
The Lancet
2009
Corpus ID: 160584
Review
2005
Review
2005
Chemotherapy and the war on cancer
B. Chabner
,
T. G. Roberts
Nature Reviews Cancer
2005
Corpus ID: 205467419
The era of chemotherapy began in the 1940s with the first uses of nitrogen mustards and antifolate drugs. Cancer drug development…
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Highly Cited
2001
Highly Cited
2001
Folic acid antagonists during pregnancy and risk of birth defects.
Brentlinger Pe
2001
Corpus ID: 18343990
A BSTRACT Background Multivitamin supplementation in pregnant women may reduce the risks of cardiovascular defects, oral clefts…
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Highly Cited
2000
Highly Cited
2000
Folic acid antagonists during pregnancy and the risk of birth defects.
S. Hernández-Díaz
,
M. Werler
,
A. Walker
,
A. Mitchell
2000
Corpus ID: 76068980
Background Multivitamin supplementation in pregnant women may reduce the risks of cardiovascular defects, oral clefts, and…
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Highly Cited
1994
Highly Cited
1994
Differential regulation of folate receptor isoforms in normal and malignant tissues in vivo and in established cell lines. Physiologic and clinical implications
J. Ross
,
P. Chaudhuri
,
M. Ratnam
Cancer
1994
Corpus ID: 10124383
Background. Despite significant differences in ligand binding between the two known isoforms of the human membrane folate…
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Review
1994
Review
1994
Supplementation with Folic Acid during Methotrexate Therapy for Rheumatoid Arthritis: A Double-Blind, Placebo-Controlled Trial
S. Morgan
,
J. Baggott
,
+6 authors
G. Alarcón
Annals of Internal Medicine
1994
Corpus ID: 30248529
The folic acid antagonist methotrexate (n-10-methyl-aminopterin) is useful in low doses (2.5 to 20 mg/wk) for treating chronic…
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Highly Cited
1993
Highly Cited
1993
The antiinflammatory mechanism of methotrexate. Increased adenosine release at inflamed sites diminishes leukocyte accumulation in an in vivo model of inflammation.
B. Cronstein
,
D. Naime
,
E. Ostad
The Journal of clinical investigation
1993
Corpus ID: 17943674
Methotrexate, a folate antagonist, is a potent antiinflammatory agent when used weekly in low concentrations. We examined the…
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Highly Cited
1988
Highly Cited
1988
Evidence that a point mutation in dihydrofolate reductase-thymidylate synthase confers resistance to pyrimethamine in falciparum malaria.
D. Peterson
,
D. Walliker
,
T. Wellems
Proceedings of the National Academy of Sciences…
1988
Corpus ID: 1049447
Analysis of a genetic cross of Plasmodium falciparum and of independent parasite isolates from Southeast Asia, Africa, and South…
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Highly Cited
1986
Highly Cited
1986
Binding of a specific ligand inhibits import of a purified precursor protein into mitochondria
M. Eilers
,
G. Schatz
Nature
1986
Corpus ID: 4343617
Methotrexate, a folate antagonist, blocks import into mitochondria of mouse dihydrofolate reductase fused to a mitochondrial…
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Highly Cited
1948
Highly Cited
1948
Temporary remissions in acute leukemia in children produced by folic acid antagonist, 4-aminopteroyl-glutamic acid.
S. Farber
,
L. Diamond
The New England journal of medicine
1948
Corpus ID: 30856610
IT IS the purpose of this paper to record the results of clinical and hematologic studies on 5 children with acute leukemia…
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