Folic Acid Antagonists

Known as: Folate Analog, Antifolates, Antagonists, Folic Acid 
Inhibitors of the enzyme, dihydrofolate reductase (TETRAHYDROFOLATE DEHYDROGENASE), which converts dihydrofolate (FH2) to tetrahydrofolate (FH4… (More)
National Institutes of Health

Related topics

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46 relations

Narrower (37)

10-deazaaminopterin1843U893',5'-dichloromethotrexate3'-fluoroaminopterin
(More)
AntimetabolitesAntimetabolites, AntineoplasticDihydrofolate Reductase InhibitorsFolic acid analogs, antimetabolites
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Broader (1)

vitamin antagonist

Papers overview

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Highly Cited
2009
Highly Cited
2009
Maintenance pemetrexed plus best supportive care versus placebo plus best supportive care for non-small-cell lung cancer: a randomised, double-blind, phase 3 study
BACKGROUND Several studies have shown the efficacy, tolerability, and ease of administration of pemetrexed-an antifolate… (More)
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Highly Cited
2008
Highly Cited
2008
Is folic acid good for everyone?
Fortification of food with folic acid to reduce the number of neural tube defects was introduced 10 y ago in North America. Many… (More)
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Highly Cited
2005
Highly Cited
2005
Randomized phase III study of cisplatin with or without raltitrexed in patients with malignant pleural mesothelioma: an intergroup study of the European Organisation for Research and Treatment of…
PURPOSE We conducted a phase III trial to determine whether first-line treatment with raltitrexed, a thymidine synthase inhibitor… (More)
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Highly Cited
2002
Highly Cited
2002
Molecular markers for failure of sulfadoxine-pyrimethamine and chlorproguanil-dapsone treatment of Plasmodium falciparum malaria.
Molecular assays for monitoring sulfadoxine-pyrimethamine-resistant Plasmodium falciparum have not been implemented because of… (More)
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Highly Cited
2001
Highly Cited
2001
Neural tube defects in relation to use of folic acid antagonists during pregnancy.
Periconceptional folic acid supplementation reduces the risk of neural tube defects (NTDs). To determine whether periconceptional… (More)
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Highly Cited
2000
Highly Cited
2000
FOLIC ACID ANTAGONISTS DURING PREGNANCY AND THE RISK OF BIRTH DEFECTS
  • ONIA, ERNÁNDEZ, +9 authors ITCHELL
  • 2000
A BSTRACT Background Multivitamin supplementation in pregnant women may reduce the risks of cardiovascular defects, oral clefts… (More)
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Highly Cited
1994
Highly Cited
1994
Differential regulation of folate receptor isoforms in normal and malignant tissues in vivo and in established cell lines. Physiologic and clinical implications.
BACKGROUND Despite significant differences in ligand binding between the two known isoforms of the human membrane folate receptor… (More)
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Highly Cited
1988
Highly Cited
1988
Evidence that a point mutation in dihydrofolate reductase-thymidylate synthase confers resistance to pyrimethamine in falciparum malaria.
Analysis of a genetic cross of Plasmodium falciparum and of independent parasite isolates from Southeast Asia, Africa, and South… (More)
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Highly Cited
1988
Highly Cited
1988
Amino acid changes linked to pyrimethamine resistance in the dihydrofolate reductase-thymidylate synthase gene of Plasmodium falciparum.
We describe the isolation and the sequence of the gene for the bifunctional enzyme dihydrofolate reductase-thymidylate synthase… (More)
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Highly Cited
1948
Highly Cited
1948
Temporary remissions in acute leukemia in children produced by folic acid antagonist, 4-aminopteroyl-glutamic acid.
 
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