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Folic acid analogs, antimetabolites

Known as: Folic Acid Analogue, Folic Acid Derivative, Folic acid analogues 
A substance derived from folic acid that acts as a precursor or cofactor of enzymes and inhibitors involved in biosynthesis of amino acids, proteins… 
National Institutes of Health

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Folic Acid Antagonists

Papers overview

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2009
2009
Fluorometry of singlet oxygen generated via a photosensitized reaction using folic acid and methotrexate
AbstractA method for the fluorometry of singlet oxygen (1O2) using less fluorescent folic acid and its analogue, methotrexate… 
Highly Cited
2008
Highly Cited
2008
Fluorine-18 click radiosynthesis and preclinical evaluation of a new 18F-labeled folic acid derivative.
The folate receptor (FR) is highly expressed on most epithelial cancer cells, while normal cells show only restricted expression… 
2004
2004
Structural determinants for the intracellular degradation of human thymidylate synthase.
Thymidylate synthase (EC 2.1.1.45) (TS) catalyzes the conversion of dUMP to dTMP and is therefore indispensable for DNA… 
1996
1996
Local concentration of folate binding protein GP38 in sections of human ovarian carcinoma by in vitro quantitative autoradiography.
UNLABELLED Folate binding protein (FBP) GP38 is a membrane-associated glycoprotein that mediates the intracellular transport of… 
1971
1971
T4 bacteriophage-specific dihydrofolate reductase: purification to homogeneity by affinity chromatography.
1970
1970
Synchronization of DNA synthesis in Tetrahymena populations by temporary limitation of access to thymine compounds.
Highly Cited
1969
Highly Cited
1969
Transport energetics of the folic acid analogue, methotrexate, in L1210 leukemia cells. Enhanced accumulation by metabolic inhibitors.
Abstract Energy-dependent transport of the folic acid analogue, methotrexate, was studied in L1210 murine leukemia cells. A… 
1968
1968
Thymine starvation by inhibition of uptake and synthesis of thymine-compounds in Tetrahymena.
1960
1960
Reduced Folic Acid Analogues as Antimetabolites
HYDROGENATION of the folic acid analogues aminopterin (4-aminopteroylglutamic acid) and amethopterin (N10-methyl-4… 
1958
1958
Serine–Glycine Interconversion in Plant Tissues
THE conversion of serine to glycine in animal tissues was first demonstrated by Shemin1 by a feeding experiment using serine… 
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