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Identification of an Intestinal Folate Transporter and the Molecular Basis for Hereditary Folate Malabsorption
Mechanisms of membrane transport of folates into cells and across epithelia.
Until recently, the transport of folates into cells and across epithelia has been interpreted primarily within the context of two transporters with high affinity and specificity for folates, the…
Membrane transporters and folate homeostasis: intestinal absorption and transport into systemic compartments and tissues
This review focuses on the physiological roles of the major folate transporters, with a brief consideration of their impact on the pharmacological activities of antifolates.
Pemetrexed: biochemical and cellular pharmacology, mechanisms, and clinical applications
The history of antifolates that led to the development of pemetrexed is traced and the unique properties of this agent are described, including its very rapid conversion to active polyglutamate derivatives in cells and its marked sensitivity to the level of physiologic folates in cells.
Resistance to antifolates
How insights from the exploration and understanding of mechanisms of resistance to a variety of diverse antineoplastics with different cellular targets are being utilized to develop gene therapy approaches to protect normal bone marrow progenitor cells as a strategy to improve the efficacy of bone marrow transplantation is described.
Schedule-Dependent Cytotoxic Synergism of Pemetrexed and Erlotinib in Human Non–Small Cell Lung Cancer Cells
- Tianhong Li, Y. Ling, I. Goldman, R. Perez-soler
- Biology, MedicineClinical Cancer Research
- 1 June 2007
The combination of pemetrexed and erlot inib is synergistic in NSCLC in vitro if exposure to erlotinib before pemet Rexed is avoided, particularly in tumors that are sensitive to er Lotonib.
THE CHARACTERISTICS OF THE MEMBRANE TRANSPORT OF AMETHOPTERIN AND THE NATURALLY OCCURRING FOLATES
- I. Goldman
- BiologyAnnals of the New York Academy of Sciences
- 1 November 1971
Studies are described which characterize a number of aspects of MTX transport in L12 I0 leukemia cells, Ehrlich ascites tumor cells, and rabbit erythrocytes which relate these findings to the transport characteristics of the naturally occurring folatcs.
Rescue of Embryonic Lethality in Reduced Folate Carrier-deficient Mice by Maternal Folic Acid Supplementation Reveals Early Neonatal Failure of Hematopoietic Organs*
The data indicate that in the absence of RFC1 function, neonatal animals die due to failure of hematopoietic organs.
The molecular identity and characterization of a Proton-Coupled Folate Transporter—PCFT; biological ramifications and impact on the activity of pemetrexed—12 06 06
The key role this transporter plays in intestinal folate absorption has been confirmed by the demonstration of a mutation in this gene in the rare autosomal recessive disorder, hereditary folate malabsorption.