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1843U89

Known as: BW 1843U89, BW-1843U89, Pentanedioic acid, 2-(5-(((1,2-dihydro-3-methyl-1-oxobenzo(f)quinazolin-9-yl)methyl)amino)-1,3-dihydro-1-oxo-2H-isoindol-2-yl)-, (S)- 
National Institutes of Health

Related topics

Related topics

7 relations
1843UGW1843

Broader (5)

Antineoplastic AgentsEnzyme InhibitorsFolic Acid AntagonistsIsoindoles

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2006
2006
Benzoquinazoline Inhibitor of Thymidylate Synthase Biochemical and Cellular Pharmacology of 1843 U 89 , a Novel Updated
Studies on a series of benzoquinazoline folate analogues as inhibitors of human thymidylate synthase led to the selection of… 
2004
2004
Destruction of WiDr multicellular tumor spheroids with the novel thymidylate synthase inhibitor 1843U89 at physiological thymidine concentrations
The activity of a novel thymidylate synthase inhibitor, 1843U89, against WiDr human colon carcinoma multicellular tumor spheroids… 
2001
2001
A phase I and pharmacokinetic study of 1843U89, a noncompetitive inhibitor of thymidylate synthase, in patients with advanced solid malignancies.
This study was performed to assess the feasibility of administering 1843U89, a potent, noncompetitive inhibitor of thymidylate… 
1996
1996
In vitro uptake, anabolism, and cellular retention of 1843U89 and other benzoquinazoline inhibitors of thymidylate synthase.
1843U89 is a potent inhibitor (Ki = 0.09 nM) of thymidylate synthase (TS; EC 2.1.1.45) that is in clinical trial for the… 
1995
1995
Ligand-induced distortion of an active site in thymidylate synthase upon binding anticancerdrug 1843U89
The anticancer drug 1843U89 inhibits thymidylate synthase (TS) at sub-nanomolar concentrations and is undergoing clinical trial… 
1995
1995
Promotion of purine nucleotide binding to thymidylate synthase by a potent folate analogue inhibitor, 1843U89.
A folate analogue, 1843U89 (U89), with potential as a chemotherapeutic agent due to its potent and specific inhibition of… 
1995
1995
Antitumor activity of antifolate inhibitors of thymidylate and purine synthesis in human soft tissue sarcoma cell lines with intrinsic resistance to methotrexate.
We examined the antitumor effects of two antifolate inhibitors of thymidylate synthesis, N-(5-[N-(3, 4-dihydro-2-methyl-4… 
Highly Cited
1994
Highly Cited
1994
Mode of binding of folate analogs to thymidylate synthase. Evidence for two asymmetric but interactive substrate binding sites.
1993
1993
Determinants of the disparate antitumor activities of (6R)-5,10-dideaza-5,6,7,8-tetrahydrofolate and methotrexate toward human lymphoblastic leukemia cells, characterized by severely impaired…
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