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Antimetabolites

Known as: Antimetabolite 
An antineoplastic agent with a structural similarity to a natural substance that can replace that substance in a normal biochemical pathway and… Expand
National Institutes of Health

Papers overview

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Highly Cited
2012
Highly Cited
2012
BACKGROUND & AIMS It is important to determine whether infliximab therapy can be safely interrupted in patients with Crohn's… Expand
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Highly Cited
2010
Highly Cited
2010
This paper is the second in a series of three publications relating to the European evidence-based consensus on the diagnosis and… Expand
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Review
2009
Review
2009
  • W. Parker
  • Chemical reviews
  • 2009
  • Corpus ID: 19814435
Inhibition of cellular replication is one characteristic of cancer cells that has been effectively exploited in the past for the… Expand
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Highly Cited
2005
Highly Cited
2005
Drug treatment of colorectal cancer has made impressive progress during the past 10 years. In addition to the traditional 5… Expand
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Review
2000
Review
2000
Most current chemotherapy regimens for cancer consist of empirically designed combinations, based on efficacy and lack of… Expand
Highly Cited
1999
Highly Cited
1999
We have examined the effects of commonly used chemotherapeutic agents on human colon cancer cell lines in which the p53 pathway… Expand
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Highly Cited
1999
Highly Cited
1999
BACKGROUND Brain tumours rarely occur in survivors of childhood acute lymphoblastic leukaemia after cranial radiotherapy. An… Expand
Highly Cited
1997
Highly Cited
1997
In the present study, we report the characterization of the p53 tumor suppressor pathway in the 60 cell lines of the National… Expand
Review
1980
Review
1980
Clinical features and specific aspects of treatment were evaluated in 612 patients with gram-negative bacteremia observed over a… Expand
Highly Cited
1953
Highly Cited
1953
1. A new antimetabolite, 6-mercaptopurine, has been shown to produce good clinical and hematologic remissions in fifteen out of… Expand