Antimetabolites

Known as: Antimetabolite 
An antineoplastic agent with a structural similarity to a natural substance that can replace that substance in a normal biochemical pathway and… (More)
National Institutes of Health

Papers overview

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Review
2017
Review
2017
Cancer has long been a grievous disease complicated by innumerable players aggravating its cure. Many clinical studies… (More)
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Highly Cited
2012
Highly Cited
2012
BACKGROUND & AIMS It is important to determine whether infliximab therapy can be safely interrupted in patients with Crohn's… (More)
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Highly Cited
2012
Highly Cited
2012
Many anticancer agents damage DNA and arrest cell-cycle progression primarily in S or G(2) phase of the cell cycle. Previous… (More)
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Highly Cited
2010
Highly Cited
2010
The serine/threonine kinase Akt lies at a critical signaling node downstream of phosphatidylinositol-3-kinase and is important in… (More)
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Highly Cited
2007
Highly Cited
2007
In the context of pancreatic cancer, metastasis remains the most critical determinant of resectability, and hence survival. The… (More)
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Review
2000
Review
2000
Most current chemotherapy regimens for cancer consist of empirically designed combinations, based on efficacy and lack of… (More)
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Highly Cited
1999
Highly Cited
1999
BACKGROUND Brain tumours rarely occur in survivors of childhood acute lymphoblastic leukaemia after cranial radiotherapy. An… (More)
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Highly Cited
1999
Highly Cited
1999
We have examined the effects of commonly used chemotherapeutic agents on human colon cancer cell lines in which the p53 pathway… (More)
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Review
1998
Review
1998
It is almost 50 years since antimetabolites were first found to have clinical antitumour activity, with Farber's discovery that… (More)
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Highly Cited
1997
Highly Cited
1997
In the present study, we report the characterization of the p53 tumor suppressor pathway in the 60 cell lines of the National… (More)
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