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Artemisinin resistance in Plasmodium falciparum malaria.
BACKGROUND Artemisinin-based combination therapies are the recommended first-line treatments of falciparum malaria in all countries with endemic disease. There are recent concerns that the efficacyExpand
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Complete genome sequence of a multiple drug resistant Salmonella enterica serovar Typhi CT18
Salmonella enterica serovar Typhi (S. typhi) is the aetiological agent of typhoid fever, a serious invasive bacterial disease of humans with an annual global burden of approximately 16 million cases,Expand
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Spread of artemisinin resistance in Plasmodium falciparum malaria.
BACKGROUND Artemisinin resistance in Plasmodium falciparum has emerged in Southeast Asia and now poses a threat to the control and elimination of malaria. Mapping the geographic extent of resistanceExpand
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Antimalarial drug resistance.
  • N. White
  • Biology, Medicine
  • The Journal of clinical investigation
  • 15 April 2004
Malaria, the most prevalent and most pernicious parasitic disease of humans, is estimated to kill between one and two million people, mainly children, each year. Resistance has emerged to all classesExpand
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Qinghaosu (Artemisinin): The Price of Success
Artemisinin and its derivatives have become essential components of antimalarial treatment. These plant-derived peroxides are unique among antimalarial drugs in killing the young intraerythrocyticExpand
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Emergence of artemisinin-resistant malaria on the western border of Thailand: a longitudinal study
Summary Background Artemisinin-resistant falciparum malaria has arisen in western Cambodia. A concerted international effort is underway to contain artemisinin-resistant Plasmodium falciparum, butExpand
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Assessment of the pharmacodynamic properties of antimalarial drugs in vivo.
  • N. White
  • Medicine
  • Antimicrobial agents and chemotherapy
  • 1 July 1997
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Melioidosis: insights into the pathogenicity of Burkholderia pseudomallei
Burkholderia pseudomallei is a potential bioterror agent and the causative agent of melioidosis, a severe disease that is endemic in areas of Southeast Asia and Northern Australia. Infection is oftenExpand
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Artesunate versus quinine in the treatment of severe falciparum malaria in African children (AQUAMAT): an open-label, randomised trial
Summary Background Severe malaria is a major cause of childhood death and often the main reason for paediatric hospital admission in sub-Saharan Africa. Quinine is still the established treatment ofExpand
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Melioidosis: a major cause of community-acquired septicemia in northeastern Thailand.
In a prospective study of all patients with Pseudomonas pseudomallei infections admitted to a large provincial hospital in northeastern Thailand, 63 cases of septicemic melioidosis and 206 patientsExpand
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