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Artemisinin resistance in Plasmodium falciparum malaria.
P. falciparum has reduced in vivo susceptibility to artesunate in western Cambodia as compared with northwestern Thailand, and resistance is characterized by slow parasite clearance in vivo without corresponding reductions on conventional in vitro susceptibility testing.
Complete genome sequence of a multiple drug resistant Salmonella enterica serovar Typhi CT18
The genome sequence is sequenced of a S. typhi (CT18) that is resistant to multiple drugs, revealing the presence of hundreds of insertions and deletions compared with the Escherichia coli genome, ranging in size from single genes to large islands.
Spread of artemisinin resistance in Plasmodium falciparum malaria.
Prolonged courses of artemisinin-based combination therapies are currently efficacious in areas where standard 3-day treatments are failing, and the incidence of pretreatment and post-treatment gametocytemia was higher among patients with slow parasite clearance, suggesting greater potential for transmission.
Antimalarial drug resistance.
- N. White
- Medicine, BiologyThe Journal of clinical investigation
- 15 April 2004
Widespread use of these drugs could roll back malaria and Artemisinin-derivative combinations are particularly effective, since they act rapidly and are well tolerated and highly effective.
Qinghaosu (Artemisinin): The Price of Success
- N. White
- 18 April 2008
Artemisinin combination treatments are now first-line drugs for uncomplicated falciparum malaria, but access to ACTs is still limited in most malaria-endemic countries and a global subsidy would make these drugs more affordable and available.
Mefloquine resistance in Plasmodium falciparum and increased pfmdr1 gene copy number
Melioidosis: a major cause of community-acquired septicemia in northeastern Thailand.
Septicemic melioidosis presented mainly in the rainy season, occurred predominantly in rice farmers or their families, and was significantly associated with preexisting diabetes mellitus or renal failure, and the mortality was high.
Melioidosis: insights into the pathogenicity of Burkholderia pseudomallei
Prevention of disease and a reduction in mortality and the rate of relapse are priority areas for future research efforts, and how the disease is acquired and the host–pathogen interactions involved will underpin these efforts are presented.
Assessment of the pharmacodynamic properties of antimalarial drugs in vivo
- N. White
- Medicine, BiologyAntimicrobial agents and chemotherapy
- 1 July 1997
Assessment of the therapeutic response in falciparum malaria is complicated by the loose relationship between parasitemia (number of parasites per unit volume of blood) and disease severity, which reflects a change in the relationship between parasite burden and both the release of and the response to illness-inducing cytokines.
Human cerebral malaria. A quantitative ultrastructural analysis of parasitized erythrocyte sequestration.
- G. Macpherson, M. Warrell, N. White, S. Looareesuwan, D. Warrell
- Medicine, BiologyThe American journal of pathology
- 1 June 1985
It is concluded that there is no evidence for an inflammatory or immune pathogenesis for human cerebral malaria and that the clinical effects probably relate to anoxia and the metabolic activities of the parasites.