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Complete genome sequence of a multiple drug resistant Salmonella enterica serovar Typhi CT18
Salmonella enterica serovar Typhi (S. typhi) is the aetiological agent of typhoid fever, a serious invasive bacterial disease of humans with an annual global burden of approximately 16 million cases,Expand
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The epidemiology of melioidosis in Ubon Ratchatani, northeast Thailand.
BACKGROUND Melioidosis, or infection with Pseudomonas pseudomallei is an important cause of morbidity and mortality in South East Asia and Northern Australia. The epidemiology of melioidosis in UbonExpand
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Vivax malaria: neglected and not benign.
Plasmodium vivax threatens almost 40% of the world's population, resulting in 132-391 million clinical infections each year. Most of these cases originate from Southeast Asia and the Western Pacific,Expand
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Multiple populations of artemisinin-resistant Plasmodium falciparum in Cambodia
We describe an analysis of genome variation in 825 P. falciparum samples from Asia and Africa that identifies an unusual pattern of parasite population structure at the epicenter of artemisininExpand
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A selective sweep driven by pyrimethamine treatment in southeast asian malaria parasites.
Malaria parasites (Plasmodium falciparum) provide an excellent system in which to study the genomic effects of strong selection in a recombining eukaryote because the rapid spread of resistance toExpand
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Artemisinin-based combination treatment of falciparum malaria.
  • F. Nosten, N. White
  • Medicine
  • The American journal of tropical medicine and…
  • 1 December 2007
Artemisinin-based combination treatments (ACTs) are now generally accepted as the best treatments for uncomplicated falciparum malaria. They are rapidly and reliably effective. Efficacy is determinedExpand
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Early Origin and Recent Expansion of Plasmodium falciparum
The emergence of virulent Plasmodium falciparumin Africa within the past 6000 years as a result of a cascade of changes in human behavior and mosquito transmission has recently been hypothesized.Expand
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Population transcriptomics of human malaria parasites reveals the mechanism of artemisinin resistance
Mechanisms propelling drug resistance If it were to spread, resistance to the drug artemisinin would seriously derail the recent gains of global malaria control programs (see the Perspective byExpand
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Estimation of the Total Parasite Biomass in Acute Falciparum Malaria from Plasma PfHRP2
Background In falciparum malaria sequestration of erythrocytes containing mature forms of Plasmodium falciparum in the microvasculature of vital organs is central to pathology, but quantitation ofExpand
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Two nonrecombining sympatric forms of the human malaria parasite Plasmodium ovale occur globally.
BACKGROUND Malaria in humans is caused by apicomplexan parasites belonging to 5 species of the genus Plasmodium. Infections with Plasmodium ovale are widely distributed but rarely investigated, andExpand
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