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THE IMPORTANCE OF MOSQUITO BEHAVIOURAL ADAPTATIONS TO MALARIA CONTROL IN AFRICA
Determining the public health impact of physiological and behavioral insecticide resistance is an urgent priority if the authors are to maintain the significant gains made in reducing malaria morbidity and mortality.
The origins of antimalarial drug resistance.
- I. Hastings
- MedicineTrends in parasitology
- 1 November 2004
Malaria and Irrigated Crops, Accra, Ghana
- E. Klinkenberg, P. McCall, I. Hastings, M. Wilson, F. Amerasinghe, M. Donnelly
- MedicineEmerging infectious diseases
- 1 August 2005
The findings indicate that African urban poor are seriously affected by malaria and that irrigated agriculture may increase this risk.
The evolution of drug-resistant malaria: the role of drug elimination half-life.
- I. Hastings, W. Watkins, N. White
- BiologyPhilosophical transactions of the Royal Society…
- 29 April 2002
The methodology has been extended to investigate the effects of using drugs in combination, particularly when the components have differing half-lives, and the specific example of the development of resistance to the antimalarial pyrimethamine-sulphadoxine.
Intensity of malaria transmission and the evolution of drug resistance.
Population genetic aspects of deleterious cytoplasmic genomes and their effect on the evolution of sexual reproduction.
- I. Hastings
- BiologyGenetical research
- 1 June 1992
The analysis described here predicts a large, rapid reduction in fitness associated with isogamous sexual reproduction, due to the spread of deleterious cytoplasmic agents with fitness only subsequently rising to a maximum twofold cost as uniparental inheritance of cy toplasm and anisogamy evolve.
A model for the origins and spread of drug-resistant malaria
- I. Hastings
- 1 August 1997
A general method of investigating parasite population genetics is presented and used to investigate the evolution of drug resistance in Plasmodium, identifying the implicit assumptions made in several previous models, reconcile their differing conclusions and allow a more informed debate about the practical application of drugs.
Antimalarial drug resistance, artemisinin-based combination therapy, and the contribution of modeling to elucidating policy choices.
- S. Yeung, W. Pongtavornpinyo, I. Hastings, A. Mills, N. White
- MedicineThe American journal of tropical medicine and…
- 1 August 2004
The difficulties in measuring the burden of drug resistance and predicting the impact of strategies aimed at its reduction are outlined, and a mathematical model is introduced that is being designed to address these issues and to clarify policy options.
Tolerance is the key to understanding antimalarial drug resistance.
Climate prediction of El Niño malaria epidemics in north-west Tanzania
- Anne E Jones, U. U. Wort, Andrew P. Morse, I. Hastings, A. Gagnon
- Medicine, Environmental ScienceMalaria Journal
- 6 December 2007
The potential of a seasonal forecasting system in the development of a malaria early warning system in Kagera region is demonstrated and it is found that malaria incidence is positively correlated with rainfall.