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THE IMPORTANCE OF MOSQUITO BEHAVIOURAL ADAPTATIONS TO MALARIA CONTROL IN AFRICA
Over the past decade the use of long‐lasting insecticidal nets (LLINs), in combination with improved drug therapies, indoor residual spraying (IRS), and better health infrastructure, has helpedExpand
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The origins of antimalarial drug resistance.
  • I. Hastings
  • Biology, Medicine
  • Trends in parasitology
  • 1 November 2004
Resistance of Plasmodium falciparum to the antimalarial drug sulfadoxine-pyrimethamine is a result of extremely rare mutations that have spread over large geographical areas. This pattern wasExpand
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Malaria and Irrigated Crops, Accra, Ghana
We investigated the prevalence of malaria and associated risk factors in children living in urban Ghana. Malaria prevalence was associated with low hemoglobin concentration, low socioeconomic status,Expand
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The evolution of drug-resistant malaria: the role of drug elimination half-life.
This paper seeks to define and quantify the influence of drug elimination half-life on the evolution of antimalarial drug resistance. There are assumed to be three general classes of susceptibilityExpand
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Antimalarial drug resistance, artemisinin-based combination therapy, and the contribution of modeling to elucidating policy choices.
Increasing resistance of Plasmodium falciparum malaria to antimalarial drugs is posing a major threat to the global effort to "Roll Back Malaria". Chloroquine and sulfadoxine-pyrimethamine (SP) areExpand
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Intensity of malaria transmission and the evolution of drug resistance.
The intensity of malaria transmission varies both naturally and as a consequence of human public health intervention. The relationship between transmission intensity and the rate at whichExpand
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Population genetic aspects of deleterious cytoplasmic genomes and their effect on the evolution of sexual reproduction.
  • I. Hastings
  • Biology, Medicine
  • Genetical research
  • 1 June 1992
A conflict of interest may arise between intra-cellular genomes and their host cell. The example explicitly investigated is that of a 'selfish' mitochondrion which increases its own rate ofExpand
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Tolerance is the key to understanding antimalarial drug resistance.
The evolution of antimalarial drug resistance is often considered to be a single-stage process in which parasites are either fully resistant or completely sensitive to a drug. However, this does notExpand
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Climate prediction of El Niño malaria epidemics in north-west Tanzania
BackgroundMalaria is a significant public health problem in Tanzania. Approximately 16 million malaria cases are reported every year and 100,000 to 125,000 deaths occur. Although most of Tanzania isExpand
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