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A Worldwide Map of Plasmodium falciparum K13-Propeller Polymorphisms.
No evidence of artemisinin resistance was found outside Southeast Asia and China, where resistance-associated K13 mutations were confined, and many African mutations appear to be neutral.
Age-dependent carriage of multiple Plasmodium falciparum merozoite surface antigen-2 alleles in asymptomatic malaria infections.
Both the overall number of fragments and the number of allelic types per carrier were markedly reduced around the age of 15 years, while chimeric alleles that failed to hybridize under stringent conditions to the reference probes were also observed.
The Dielmo project: a longitudinal study of natural malaria infection and the mechanisms of protective immunity in a community living in a holoendemic area of Senegal.
The findings suggest that sterile immunity and clinical protection are never fully achieved in humans continuously exposed since birth to intense transmission.
The use of remotely sensed environmental data in the study of malaria.
The present review discusses the essentials of principles, methods, advantages and limitations of remote sensing along with a presentation of ecological, meteorological and climatologic data which rule the distribution of malaria.
Evidence for an age-dependent pyrogenic threshold of Plasmodium falciparum parasitemia in highly endemic populations.
Evidence is provided for an age-dependent threshold effect of parasitemia that allows parasite density to be used to distinguish malaria attacks from other causes of fever within an individual and should facilitate the accurate evaluation of the incidence of clinical malaria in highly endemic areas.
No influence of age on infection complexity and allelic distribution in Plasmodium falciparum infections in Ndiop, a Senegalese village with seasonal, mesoendemic malaria.
The complexity of the asymptomatic infections was more than two-fold lower in Ndiop than in Dielmo and importantly, did not decrease with age, which indicates that the number of parasite types per isolate and the influence of age on complexity and allele distribution depend on the level of endemicity, consistent with the interpretation that they reflect acquired anti-parasite immunity.