• Publications
  • Influence
Malaria transmission in urban sub-Saharan Africa.
TLDR
Evidence from past literature is presented to build a conceptual framework to begin to explain this heterogeneity in malaria transmission and the potential for malaria epidemics owing to decreasing levels of natural immunity being offset by negative impacts of urbanization on the larval ecology of anopheline mosquitoes.
The public health impact of chloroquine resistance in Africa.
  • J. Trape
  • Medicine
    The American journal of tropical medicine and…
  • 2001
TLDR
It is shown that since the late 1980s convincing evidence of a major public health impact of the spread of chloroquine resistance has been available and there is an urgent need to change treatment policies in Africa.
Impact of chloroquine resistance on malaria mortality.
Microbial culturomics: paradigm shift in the human gut microbiome study.
TLDR
Culturomics complements metagenomics by overcoming the depth bias inherent in metagenomic approaches, and identifies 174 species never described previously in the human gut.
The Recent Evolution of a Maternally-Inherited Endosymbiont of Ticks Led to the Emergence of the Q Fever Pathogen, Coxiella burnetii
TLDR
This corpus of data demonstrates that C. burnetii recently evolved from an inherited symbiont of ticks which succeeded in infecting vertebrate cells, likely by the acquisition of novel virulence factors.
Gametocytemia and infectivity to mosquitoes of patients with uncomplicated Plasmodium falciparum malaria attacks treated with chloroquine or sulfadoxine plus pyrimethamine.
TLDR
Plasmodium falciparum gametocytes and their infectivity for mosquitoes were differentiated according to the drug used, its efficacy, and the duration of symptoms before treatment; they were not dependent on the density of asexual stages.
The Dielmo project: a longitudinal study of natural malaria infection and the mechanisms of protective immunity in a community living in a holoendemic area of Senegal.
TLDR
The findings suggest that sterile immunity and clinical protection are never fully achieved in humans continuously exposed since birth to intense transmission.
Age-dependent carriage of multiple Plasmodium falciparum merozoite surface antigen-2 alleles in asymptomatic malaria infections.
TLDR
Both the overall number of fragments and the number of allelic types per carrier were markedly reduced around the age of 15 years, while chimeric alleles that failed to hybridize under stringent conditions to the reference probes were also observed.
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