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NOS3 protein, human

Known as: NOS3, ECNOS protein, human, EC-NOS 
Nitric oxide synthase, endothelial (1203 aa, ~133 kDa) is encoded by the human NOS3 gene. This protein plays a role in the modulation of vascular… 
National Institutes of Health

Related topics

Related topics

17 relations
Angiogenesis PathwayAngiogenic ProcessCorticosteroid Cardioprotection PathwayEnosis

Broader (1)

Nitric Oxide Synthase Type III

Papers overview

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Highly Cited
2011
Highly Cited
2011
Epigenetic Gene Promoter Methylation at Birth Is Associated With Child’s Later Adiposity
OBJECTIVE Fixed genomic variation explains only a small proportion of the risk of adiposity. In animal models, maternal diet… 
Highly Cited
2009
Highly Cited
2009
Resveratrol induces mitochondrial biogenesis in endothelial cells
Pathways that regulate mitochondrial biogenesis are potential therapeutic targets for the amelioration of endothelial dysfunction… 
Review
2006
Review
2006
Physiological role of ROCKs in the cardiovascular system.
Rho-associated kinases (ROCKs), the immediate downstream targets of RhoA, are ubiquitously expressed serine-threonine protein… 
Highly Cited
2004
Highly Cited
2004
Carrageenan‐induced mouse paw oedema is biphasic, age‐weight dependent and displays differential nitric oxide cyclooxygenase‐2 expression
Injection of carrageenan 1% (50 μl) in the mouse paw causes a biphasic response: an early inflammatory response that lasts 6 h… 
Review
2003
Review
2003
New insights on oxidative stress and diabetic complications may lead to a "causal" antioxidant therapy.
Evidence implicates hyperglycemia-derived oxygen free radicals as mediators of diabetic complications. However, intervention… 
Highly Cited
2002
Highly Cited
2002
Rho GTPase/Rho Kinase Negatively Regulates Endothelial Nitric Oxide Synthase Phosphorylation through the Inhibition of Protein Kinase B/Akt in Human Endothelial Cells
ABSTRACT Endothelial nitric oxide synthase (eNOS) is an important regulator of cardiovascular homeostasis by production of nitric… 
Highly Cited
2001
Highly Cited
2001
Plasma nitrite rather than nitrate reflects regional endothelial nitric oxide synthase activity but lacks intrinsic vasodilator action
The plasma level of NOx, i.e., the sum of NO2− and NO3−, is frequently used to assess NO bioavailability in vivo. However, little… 
Highly Cited
1998
Highly Cited
1998
Reduced endothelial nitric oxide synthase expression and production in human atherosclerosis.
BACKGROUND NO regulates vascular tone and structure, platelets, and monocytes. NO is synthesized by endothelial NO synthase (eNOS… 
Review
1997
Review
1997
Nitric oxide synthase in models of focal ischemia.
BACKGROUND AND PURPOSE Cessation of blood flow to the brain, for even a few minutes, sets in motion a potential reversible… 
Highly Cited
1994
Highly Cited
1994
Beneficial effects and improved survival in rodent models of septic shock with S-methylisothiourea sulfate, a potent and selective inhibitor of inducible nitric oxide synthase.
Enhanced formation of nitric oxide (NO) by both the constitutive and the inducible isoforms of NO synthase (NOS) has been… 
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