Selectivity of nonsteroidal antiinflammatory drugs as inhibitors of constitutive and inducible cyclooxygenase.
- J. Mitchell, P. Akarasereenont, C. Thiemermann, R. Flower, J. Vane
- BiologyProceedings of the National Academy of Sciences…
- 15 December 1993
BF 389, an experimental drug currently being tested in humans, was the most potent and most selective inhibitor of COX-2 in intact cells, indicating there are clear pharmacological differences between the two enzymes.
Definition and drivers of acute traumatic coagulopathy: clinical and experimental investigations
- D. Frith, J. Goslings, K. Brohi
- MedicineJournal of Thrombosis and Haemostasis
- 1 September 2010
A retrospective cohort study of trauma patients admitted to five international trauma centers and corroborated the findings in a novel rat model of ATC, finding that ATC develops endogenously in response to a combination of tissue damage and shock.
Mesenchymal Stromal Cells: Current Understanding and Clinical Status
- H. Salem, C. Thiemermann
- Biology, MedicineStem Cells
- 4 December 2009
This review highlights the current understanding into the biology of MSCs with particular emphasis on the cardiovascular and renal applications, and provides a brief update on the clinical status of M SC‐based therapy.
Modulation of the oxidative stress and inflammatory response by PPAR-gamma agonists in the hippocampus of rats exposed to cerebral ischemia/reperfusion.
- M. Collino, M. Aragno, R. Fantozzi
- BiologyEuropean Journal of Pharmacology
- 13 January 2006
Nonerythropoietic, tissue-protective peptides derived from the tertiary structure of erythropoietin
It is demonstrated that helix B of EPO, which faces the aqueous medium when EPO is bound to the receptor homodimer, is both neuroprotective in vitro and tissue protective in vivo in a variety of models, including ischemic stroke, diabetes-induced retinal edema, and peripheral nerve trauma.
Beneficial effects and improved survival in rodent models of septic shock with S-methylisothiourea sulfate, a potent and selective inhibitor of inducible nitric oxide synthase.
- C. Szabó, G. Southan, C. Thiemermann
- Biology, MedicineProceedings of the National Academy of Sciences…
- 20 December 1994
S-Methylisothiourea sulfate is a potent and selective inhibitor of iNOS and exerts beneficial effects in rodent models of septic shock and may have considerable value in the therapy of circulatory shock of various etiologies and other pathophysiological conditions associated with induction of NOS.
Isothioureas: potent inhibitors of nitric oxide synthases with variable isoform selectivity
- G. Southan, C. Szabó, C. Thiemermann
- Chemistry, BiologyBritish Journal of Pharmacology
- 1 January 1995
Isothioureas represent a new class of NOS inhibitors which includes the most potent inhibitors of iNOS activity reported to date.
Inhibition of the activity of poly(ADP ribose) synthetase reduces ischemia-reperfusion injury in the heart and skeletal muscle.
- C. Thiemermann, J. Bowes, F. Myint, J. Vane
- Biology, ChemistryProceedings of the National Academy of Sciences…
- 21 January 1997
It is demonstrated that 3-aminobenzamide (and several other, chemically distinct, inhibitors of PARS activity) reduces the infarct size caused by ischemia and reperfusion of the heart or skeletal muscle of the rabbit.
ERYTHROPOIETIN ATTENUATES THE TISSUE INJURY ASSOCIATED WITH HEMORRHAGIC SHOCK AND MYOCARDIAL ISCHEMIA
- M. Abdelrahman, E. Sharples, C. Thiemermann
- Medicine, BiologyShock
- 1 July 2004
It is proposed that the acute administration of EPO on reperfusion and/or resuscitation will reduce the tissue injury caused by ischemia-reperfusion of the heart (and other organs) and hemorrhagic shock.
On the selectivity of superoxide dismutase mimetics and its importance in pharmacological studies
- C. Muscoli, S. Cuzzocrea, D. Salvemini
- Biology, ChemistryBritish Journal of Pharmacology
- 1 October 2003
This review will discuss the advances made using various superoxide dismutase mimetics that led to the proposal that superoxide (and/or the product of its interaction with nitric oxide, peroxynitrite) is an important mediator of inflammation, and to the conclusion that super poisoning mimetics can be utilized as therapeutic agents in diseases of various etiologies.
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