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The Therapeutic Potential of Poly(ADP-Ribose) Polymerase Inhibitors
The double-edged sword roles of PARP in DNA damage signaling and cell death are reviewed and the underlying mechanisms of the anti-inflammatory effects ofPARP inhibitors are summarized. Expand
Peroxynitrite: biochemistry, pathophysiology and development of therapeutics
This Review focuses on pharmacological strategies to attenuate the toxic effects of peroxynitrite, which include its catalytic reduction to nitrite and its isomerization to nitrate by metalloporphyrins, which have led to potential candidates for drug development for cardiovascular, inflammatory and neurodegenerative diseases. Expand
Hydrogen sulphide and its therapeutic potential
  • C. Szabó
  • Biology, Medicine
  • Nature Reviews Drug Discovery
  • 1 November 2007
The physiology and biochemistry of H2S is overviews, the effects of H 2S inhibitors or H2s donors in animal models of disease are summarized, the potential options for the therapeutic exploitation of H1S are outlined and they are outlined. Expand
Therapeutic Effects of Xanthine Oxidase Inhibitors: Renaissance Half a Century after the Discovery of Allopurinol
A critical overview of the effects of XO inhibitors in various pathophysiological conditions is presented and the various emerging therapeutic strategies offered by this approach are reviewed. Expand
Poly(ADP-ribose) polymerase and the therapeutic effects of its inhibitors
An overview of the principal pathophysiological pathways and mechanisms that are governed by PARP is presented, followed by the main structures and therapeutic actions of various classes of novel PARP inhibitors. Expand
Inhibition of GAPDH activity by poly(ADP-ribose) polymerase activates three major pathways of hyperglycemic damage in endothelial cells.
In this report, we show that hyperglycemia-induced overproduction of superoxide by the mitochondrial electron transport chain activates the three major pathways of hyperglycemic damage found inExpand
Multiple pathways of peroxynitrite cytotoxicity.
  • C. Szabó
  • Chemistry, Medicine
  • Toxicology letters
  • 11 April 2003
It is suggested that neutralization of peroxynitrite is of significant therapeutic benefit after exposure to various environmental toxins as well as in a variety of inflammatory and reperfusion disease conditions. Expand
Hydrogen sulfide attenuates myocardial ischemia-reperfusion injury by preservation of mitochondrial function
It is demonstrated that the delivery of H2S at the time of reperfusion limits infarct size and preserves left ventricular (LV) function in an in vivo model of myocardial ischemia-reperfusion (MI-R) and that either administration of H 2S or the modulation of endogenous production may be of clinical benefit in ischemic disorders. Expand
Hydrogen sulfide is an endogenous stimulator of angiogenesis
Investigation of the role of exogenous and endogenous hydrogen sulfide on neovascularization and wound healing in vitro and in vivo concludes that endogenous and exogenous H2S stimulates EC-related angiogenic properties through a KATP channel/MAPK pathway. Expand
Role of poly(ADP-ribose) synthetase in inflammation and ischaemia-reperfusion.
The pharmacological inhibition of poly(ADP-ribose) synthetase is a novel approach for the experimental therapy of various forms of inflammation and shock, stroke, myocardial and intestinal ischaemia-reperfusion, and diabetes mellitus. Expand