Clinical Features and Outcomes of Takotsubo (Stress) Cardiomyopathy.
- C. Templin, J. Ghadri, T. Lüscher
- Medicine, PsychologyNew England Journal of Medicine
- 2 September 2015
Patients with takotsubo cardiomyopathy had a higher prevalence of neurologic or psychiatric disorders than did those with an acute coronary syndrome and physical triggers, acute neurologics or psychiatric diseases, high troponin levels, and a low ejection fraction on admission were independent predictors for in-hospital complications.
International Expert Consensus Document on Takotsubo Syndrome (Part I): Clinical Characteristics, Diagnostic Criteria, and Pathophysiology
- J. Ghadri, I. Wittstein, C. Templin
- MedicineEuropean Heart Journal
- 29 May 2018
The clinical expert consensus document part I summarizes the current state of knowledge on clinical presentation and characteristics of TTS and agrees on controversies surrounding TTS such as nomenclature, different TTS types, role of coronary artery disease, and etiology.
Ferric carboxymaltose in patients with heart failure and iron deficiency.
- S. Anker, J. Comín Colet, P. Ponikowski
- MedicineNew England Journal of Medicine
- 17 December 2009
Treatment with intravenous ferric carboxymaltose in patients with chronic heart failure and iron deficiency, with or without anemia, improves symptoms, functional capacity, and quality of life; the side-effect profile is acceptable.
Diabetes and Vascular Disease: Pathophysiology, Clinical Consequences, and Medical Therapy: Part I
- M. Creager, T. Lüscher, F. Cosentino, J. Beckman
- Medicine, BiologyCirculation
- 23 September 2003
The present review will focus on the relationship of diabetes mellitus and atherosclerotic vascular disease, highlighting pathophysiology and molecular mechanisms (Part I) and clinical manifestations and management strategies (Part II).
Nitric oxide is responsible for flow-dependent dilatation of human peripheral conduit arteries in vivo.
- R. Joannidés, W. Haefeli, T. Lüscher
- Medicine, BiologyCirculation
- 1 March 1995
No, but not prostacyclin, is essential for flow-mediated dilatation of large human arteries, and this response can be used as a test for the L-arginine/NO pathway in clinical studies.
Enhanced Peroxynitrite Formation Is Associated with Vascular Aging
- B. van der Loo, R. Labugger, T. Lüscher
- BiologyJournal of Experimental Medicine
- 18 December 2000
Lower free nitric oxide levels in aged rat aortas are found in conjunction with a sevenfold higher expression and activity of endothelial NO synthase (eNOS), which suggests that mitochondrial dysfunction plays a major role in the vascular aging process.
The Assessment of Endothelial Function: From Research Into Clinical Practice
- A. Flammer, T. Anderson, A. Lerman
- Biology, MedicineCirculation
- 7 August 2012
The assessment of its vasodilator properties resulting from NO and other molecules may provide information on the integrity and function of the endothelium, and most, if not all, cardiovascular risk factors are associated with endothelial dysfunction, and risk factor modification leads to improvement in vascular function.
International Expert Consensus Document on Takotsubo Syndrome (Part II): Diagnostic Workup, Outcome, and Management
- J. Ghadri, I. Wittstein, C. Templin
- MedicineEuropean Heart Journal
- 29 May 2018
The clinical expert consensus statement on takotsubo syndrome (TTS) part II focuses on the diagnostic workup, outcome, and management and summarizes the diagnostic approach, which may facilitate correct and timely diagnosis.
Therapeutic Implications
- T. Lüscher, P. Vanhoutte
- BiologyEndothelium
- 15 April 2020
COVID-19 is, in the end, an endothelial disease
- P. Libby, T. Lüscher
- BiologyEuropean Heart Journal
- 21 August 2020
The concept of COVID-19 as an endothelial disease provides a unifying pathophysiological picture of this raging infection, and also provides a framework for a rational treatment strategy at a time when the authors possess an indeed modest evidence base to guide therapeutic attempts to confront this novel pandemic.
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