T. Lüscher

Publications1,971
h-index143
Citations87,075
Highly Influential Citations2,157
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Clinical Features and Outcomes of Takotsubo (Stress) Cardiomyopathy.
TLDR
Patients with takotsubo cardiomyopathy had a higher prevalence of neurologic or psychiatric disorders than did those with an acute coronary syndrome and physical triggers, acute neurologics or psychiatric diseases, high troponin levels, and a low ejection fraction on admission were independent predictors for in-hospital complications. Expand
Diabetes and Vascular Disease: Pathophysiology, Clinical Consequences, and Medical Therapy: Part I
TLDR
The present review will focus on the relationship of diabetes mellitus and atherosclerotic vascular disease, highlighting pathophysiology and molecular mechanisms (Part I) and clinical manifestations and management strategies (Part II). Expand
Ferric carboxymaltose in patients with heart failure and iron deficiency.
TLDR
Treatment with intravenous ferric carboxymaltose in patients with chronic heart failure and iron deficiency, with or without anemia, improves symptoms, functional capacity, and quality of life; the side-effect profile is acceptable. Expand
Nitric oxide is responsible for flow-dependent dilatation of human peripheral conduit arteries in vivo.
TLDR
No, but not prostacyclin, is essential for flow-mediated dilatation of large human arteries, and this response can be used as a test for the L-arginine/NO pathway in clinical studies. Expand
2014 ESC/ESA Guidelines on non-cardiac surgery: cardiovascular assessment and management: The Joint Task Force on non-cardiac surgery: cardiovascular assessment and management of the European Society…
TLDR
Clinicians will find the recommendations in these revised CPGs useful in their daily work and can be reassured that the recommendations have been vetted thoroughly by the most rigorous scientific process, so that cardiovascular clinicians worldwide may deliver optimal, standardized care. Expand
Enhanced Peroxynitrite Formation Is Associated with Vascular Aging
TLDR
Lower free nitric oxide levels in aged rat aortas are found in conjunction with a sevenfold higher expression and activity of endothelial NO synthase (eNOS), which suggests that mitochondrial dysfunction plays a major role in the vascular aging process. Expand
The Assessment of Endothelial Function: From Research Into Clinical Practice
TLDR
The assessment of its vasodilator properties resulting from NO and other molecules may provide information on the integrity and function of the endothelium, and most, if not all, cardiovascular risk factors are associated with endothelial dysfunction, and risk factor modification leads to improvement in vascular function. Expand
Drug-Eluting Stent and Coronary Thrombosis: Biological Mechanisms and Clinical Implications
TLDR
Evidence of a substantially higher risk of stent thrombosis in drug-eluting stents in DES remains inconclusive; as a consequence, both large-scale and long-term clinical trials are needed. Expand
Endothelium-dependent contractions to acetylcholine in the aorta of the spontaneously hypertensive rat.
TLDR
The reduced endothelium-dependent relaxations to acetylcholine in the SHR probably are not due to a decreased release of endot Helium-derived relaxing factor but to the simultaneous release of artery-dependent contracting substance(s). Expand
High glucose increases nitric oxide synthase expression and superoxide anion generation in human aortic endothelial cells.
TLDR
The present study demonstrates that prolonged exposure to high glucose increases eNOS gene expression, protein expression, and NO release, however, upregulation of eNos andNO release is associated with a marked concomitant increase of O2- production. Expand
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