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Anti-inflammatory properties of cytochrome P450 epoxygenase-derived eicosanoids.
The epoxyeicosatrienoic acids (EETs) are products of cytochrome P450 epoxygenases that have vasodilatory properties similar to that of endothelium-derived hyperpolarizing factor. The cytochrome P450Expand
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Interaction of oestrogen receptor with the regulatory subunit of phosphatidylinositol-3-OH kinase
Oestrogen produces diverse biological effects through binding to the oestrogen receptor (ER). The ER is a steroid hormone nuclear receptor, which, when bound to oestrogen, modulates theExpand
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Pleiotropic effects of statins.
  • J. Liao, U. Laufs
  • Biology, Medicine
  • Annual review of pharmacology and toxicology
  • 2005
Statins are potent inhibitors of cholesterol biosynthesis. In clinical trials, statins are beneficial in the primary and secondary prevention of coronary heart disease. However, the overall benefitsExpand
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HDL cholesterol, very low levels of LDL cholesterol, and cardiovascular events.
  • J. Liao
  • Medicine
  • Current atherosclerosis reports
  • 1 August 2008
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Upregulation of endothelial nitric oxide synthase by HMG CoA reductase inhibitors.
BACKGROUND Oxidized low-density lipoprotein (ox-LDL) causes endothelial dysfunction in part by decreasing the availability of endothelial nitric oxide (NO). Although HMG CoA reductase inhibitorsExpand
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Post-transcriptional Regulation of Endothelial Nitric Oxide Synthase mRNA Stability by Rho GTPase*
  • U. Laufs, J. Liao
  • Medicine, Biology
  • The Journal of Biological Chemistry
  • 11 September 1998
The mechanism by which 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase inhibitors increase endothelial nitric oxide synthase (eNOS) expression is unknown. To determine whether changes in isoprenoidExpand
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Nitric oxide decreases cytokine-induced endothelial activation. Nitric oxide selectively reduces endothelial expression of adhesion molecules and proinflammatory cytokines.
To test the hypothesis that nitric oxide (NO) limits endothelial activation, we treated cytokine-stimulated human saphenous vein endothelial cells with several NO donors and assessed their effects onExpand
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Pleiotropic effects of 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibitors.
  • M. Takemoto, J. Liao
  • Biology, Medicine
  • Arteriosclerosis, thrombosis, and vascular…
  • 1 November 2001
The 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors or statins are potent inhibitors of cholesterol biosynthesis. Several large clinical trials have demonstrated the beneficial effects ofExpand
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Physiological role of ROCKs in the cardiovascular system.
Rho-associated kinases (ROCKs), the immediate downstream targets of RhoA, are ubiquitously expressed serine-threonine protein kinases that are involved in diverse cellular functions, including smoothExpand
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Stroke protection by 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase inhibitors mediated by endothelial nitric oxide synthase.
The treatment of ischemic strokes is limited to prophylactic agents that block the coagulation cascade. Here, we show that cholesterol-lowering agents, 3-hydroxy-3-methylglutaryl (HMG)-CoA reductaseExpand
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