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Carrageenan‐induced mouse paw oedema is biphasic, age‐weight dependent and displays differential nitric oxide cyclooxygenase‐2 expression
It is demonstrated that both eNOS and iNOS expressions are dependent upon the age-weight of mice, as opposite to COX‐2 that is present only in the second phase of the oedema and is not linked to mouse age–weight. Expand
Reversal of the antiinflammatory effects of methotrexate by the nonselective adenosine receptor antagonists theophylline and caffeine: evidence that the antiinflammatory effects of methotrexate are
There is strong evidence that adenosine mediates the antiinflammatory effects of MTX in this model of RA, and the findings suggest that abstinence from caffeine, a ubiquitous food additive and medication, may enhance the therapeutic effects ofMTX in RA. Expand
Co-regulation between cyclo-oxygenase-2 and inducible nitric oxide synthase expression in the time-course of murine inflammation
The results indicate that PGE2 and NO may play in vivo mutual modulatory roles in the inflammatory response caused by zymosan injection into the mouse air pouch, a suitable model to study drugs acting on those pathways. Expand
Acetaminophen Induces Apoptosis in Rat Cortical Neurons
A direct neurotoxic action by AAP is established both in vivo and in vitro in rats at doses below those required to produce hepatotoxicity and this neurotoxicity might be involved in the general toxic syndrome observed during patient APP overdose and, possibly, also when AAP doses in the upper dosing schedule are used, especially if other risk factors are present. Expand
Endothelial nitric oxide synthase activation is critical for vascular leakage during acute inflammation in vivo.
The data collectively support the critical role for eNOS in regulating the magnitude of the acute inflammatory response and show that eNos is critical for regulating microcirculatory endothelial barrier function in vivo. Expand
HIF-1α is neuroprotective during the early phases of mild hypoxia in rat cortical neurons
Hypoxia-inducible factor 1α (HIF-1α) is a transcription factor that plays a key role in regulating the adaptive response to hypoxia. HIF-1α is stabilised during hypoxia and, after dimerisation withExpand
Barriers to Non-Viral Vector-Mediated Gene Delivery in the Nervous System
The barriers that different nanoparticles must overcome to efficiently deliver their cargo to central nervous system cells, including internalization into the neurons, interaction with intracellular organelles such as lysosomes, and transport across the nuclear membrane of the neuron in the case of DNA transfection are dealt with. Expand
Nicotinic Receptors in Neurodegeneration
The present review describes the main characteristics of nAChRs in the CNS and focuses on the various compounds that have been tested and are currently in phase I and phase II trials for the treatment of neurodegenerative diseases including PD, AD and age-associated memory and mild cognitive impairment. Expand
Protein Kinase B Activation by Reactive Oxygen Species Is Independent of Tyrosine Kinase Receptor Phosphorylation and Requires Src Activity*
Nitration of Tyr residues in PDGF-R is observed in DEM-treated cells, suggesting that ROS-induced modifications different from Tyr phosphorylation can occur at the growth factor-receptor level and can be involved in the regulation of signaling pathways. Expand
Nonviral vectors for the delivery of small interfering RNAs to the CNS.
The different approaches that are being used to efficiently deliver genetic material to neuronal tissue using nonviral vectors, including the use of cationic lipids, polyethylenimine derivatives, dendrimers, carbon nanotubes and the combination of carbon-made nanoparticles with dendedrimers are covered. Expand