Epigenetic Gene Promoter Methylation at Birth Is Associated With Child’s Later Adiposity

@inproceedings{Godfrey2011EpigeneticGP,
  title={Epigenetic Gene Promoter Methylation at Birth Is Associated With Child’s Later Adiposity},
  author={Keith M. Godfrey and A Mandaraka Sheppard and Peter Gluckman and K. A. Lillycrop and Graham C Burdge and Cameron McLean and Joanne L Rodford and Joanne L. Slater-Jefferies and Emma S. Garratt and Sarah R Crozier and Bright Starling Emerald and Catharine R Gale and Hazel M Inskip and Cyrus Cooper and Mark Hanson},
  booktitle={Diabetes},
  year={2011}
}
OBJECTIVE Fixed genomic variation explains only a small proportion of the risk of adiposity. In animal models, maternal diet alters offspring body composition, accompanied by epigenetic changes in metabolic control genes. Little is known about whether such processes operate in humans. RESEARCH DESIGN AND METHODS Using Sequenom MassARRAY we measured the methylation status of 68 CpGs 5' from five candidate genes in umbilical cord tissue DNA from healthy neonates. Methylation varied greatly at… CONTINUE READING

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