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(-)-Epicatechin mediates beneficial effects of flavanol-rich cocoa on vascular function in humans.
The data demonstrate that the human ingestion of the flavanol (-)-epicatechin is, at least in part, causally linked to the reported vascular effects observed after the consumption of flavanol-rich cocoa. Expand
Nitric oxide metabolism and breakdown.
  • M. Kelm
  • Chemistry, Medicine
  • Biochimica et biophysica acta
  • 5 May 1999
Increasing knowledge on the complex metabolism of NO in vivo will lead to the development of new therapeutic strategies to enhance bioactivity of NO via modulation of its metabolism. Expand
Sustained benefits in vascular function through flavanol-containing cocoa in medicated diabetic patients a double-masked, randomized, controlled trial.
Diets rich in flavanols reverse vascular dysfunction in diabetes, highlighting therapeutic potentials in cardiovascular disease. Expand
Nitric oxide in myocardial ischemia/reperfusion injury.
Future research on the importance of NO in ischemia/reperfusion injury will have to focus more precisely on the identification and standardization of potential confounding experimental factors that influence synthesis, transport, and interaction of NO with various targets in blood and tissue. Expand
Plasma nitrite reflects constitutive nitric oxide synthase activity in mammals.
Evidence is provided for a uniform constitutive vascular NOS-activity across mammalian species by determining plasma nitrite concentration to be in a nanomolar range in a variety of species. Expand
Plasma nitrite rather than nitrate reflects regional endothelial nitric oxide synthase activity but lacks intrinsic vasodilator action
  • T. Lauer, M. Preik, +4 authors M. Kelm
  • Chemistry, Medicine
  • Proceedings of the National Academy of Sciences…
  • 16 October 2001
The results contradict the current paradigm that plasma NO3− and/or total NOx are generally useful markers of endogenous NO production and demonstrate that only NO2− reflects acute changes in regional eNOS activity and physiological levels of nitrite are vasodilator-inactive. Expand
Red blood cells express a functional endothelial nitric oxide synthase.
Evidence is provided that RBCs from humans express an active and functional endothelial-type NOS (eNOS), which is localized in the plasma membrane and the cytoplasm of R BCs, which is regulated by its substrate L-arginine, by calcium, and by phosphorylation via PI3 kinase. Expand
Control of coronary vascular tone by nitric oxide.
NO, the most rapidly acting vasodilator presently known, is metabolized within the heart mainly to nitrite and exhibits a half-life of only 0.1 second; in the unstimulated heart, basal formation of NO may play an important role in setting the resting tone of coronary resistance vessels; the kinetics and quantities of NO formation suggest that NO is causally involved in the bradykinin-induced coronary vasodilation. Expand
Impaired progenitor cell activity in age-related endothelial dysfunction.
Investigation of whether human age-related endothelial dysfunction is accompanied by quantitative and qualitative alterations of the endothelial progenitor cell (EPC) pool found maintenance of vascular homeostasis by EPCs may be attenuated with age based on functional deficits rather than depletion of CD34/KDR or CD133/K DR cells. Expand