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Aging-Induced Phenotypic Changes and Oxidative Stress Impair Coronary Arteriolar Function
We aimed to elucidate the possible role of phenotypic alterations and oxidative stress in age-related endothelial dysfunction of coronary arterioles. Arterioles were isolated from the hearts of youngExpand
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Mechanisms of vascular aging: new perspectives.
This review focuses on molecular, cellular, and functional changes that occur in the vasculature during aging; explores the links between mitochondrial oxidative stress, inflammation, and developmentExpand
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Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life span.
A small molecule that safely mimics the ability of dietary restriction (DR) to delay age-related diseases in laboratory animals is greatly sought after. We and others have shown that resveratrolExpand
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Resveratrol induces mitochondrial biogenesis in endothelial cells.
Pathways that regulate mitochondrial biogenesis are potential therapeutic targets for the amelioration of endothelial dysfunction and vascular disease. Resveratrol was shown to impact mitochondrialExpand
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Mitochondria and cardiovascular aging.
Old age is a major risk factor for cardiovascular diseases. Several lines of evidence in experimental animal models have indicated the central role of mitochondria both in lifespan determination andExpand
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Resveratrol confers endothelial protection via activation of the antioxidant transcription factor Nrf2.
Epidemiological studies suggest that Mediterranean diets rich in resveratrol are associated with reduced risk of coronary artery disease. Resveratrol was also shown to confer vasoprotection in animalExpand
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CB2-receptor stimulation attenuates TNF-alpha-induced human endothelial cell activation, transendothelial migration of monocytes, and monocyte-endothelial adhesion.
Targeting cannabinoid-2 (CB(2)) receptors with selective agonists may represent a novel therapeutic avenue in various inflammatory diseases, but the mechanisms by which CB(2) activation exerts itsExpand
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Increased Superoxide Production in Coronary Arteries in Hyperhomocysteinemia: Role of Tumor Necrosis Factor-&agr;, NAD(P)H Oxidase, and Inducible Nitric Oxide Synthase
Objective—In coronary arteries, hyperhomocysteinemia (HHcy, a known risk factor for coronary heart disease) impairs flow-induced dilations, which can be reversed by superoxide dismutase (SOD). ToExpand
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Vasculoprotective Effects of Anti-Tumor Necrosis Factor-α Treatment in Aging
Vascular aging is associated with dysregulation of tumor necrosis factor (TNF)-α expression. TNF-α is a master regulator of vascular proatherogenic phenotypic changes, and it has been linked toExpand
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Inflammation and endothelial dysfunction during aging: role of NF-kappaB.
One of the major conceptual advances in our understanding of the pathogenesis of age-associated cardiovascular diseases has been the insight that age-related oxidative stress may promote vascularExpand
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