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Diabetic endothelial dysfunction: the role of poly(ADP-ribose) polymerase activation
Treatment with a novel potent PARP inhibitor, starting after the time of islet destruction, maintained normal vascular responsiveness, despite the persistence of severe hyperglycemia, indicating that PARP may be a novel drug target for the therapy of diabetic endothelial dysfunction. Expand
Beneficial effects and improved survival in rodent models of septic shock with S-methylisothiourea sulfate, a potent and selective inhibitor of inducible nitric oxide synthase.
S-Methylisothiourea sulfate is a potent and selective inhibitor of iNOS and exerts beneficial effects in rodent models of septic shock and may have considerable value in the therapy of circulatory shock of various etiologies and other pathophysiological conditions associated with induction of NOS. Expand
Selective pharmacological inhibition of distinct nitric oxide synthase isoforms.
The enzymatic mechanism of NO production is surveyed, the strategies and pharmacological tools for selective inhibition of distinct NOS isoforms are listed, and the side-effects of the various approaches are considered. Expand
Isothioureas: potent inhibitors of nitric oxide synthases with variable isoform selectivity
Isothioureas represent a new class of NOS inhibitors which includes the most potent inhibitors of iNOS activity reported to date. Expand
Poly(ADP-ribose) polymerase inhibitors.
The structures and pharmacological actions of various pharmacological classes of compounds which inhibit the catalytic activity of PARP are overviewed and may have additional, potential utility as anticancer agents, radiosensitizers and antiviral agents. Expand
Inosine Inhibits Inflammatory Cytokine Production by a Posttranscriptional Mechanism and Protects Against Endotoxin-Induced Shock1
Inosine suppressed proinflammatory cytokine production and mortality in a mouse endotoxemic model and suggests that this agent may be useful in the treatment of inflammatory/ischemic diseases. Expand
Localizing antithrombotic and vasodilatory activity with a novel, ultrafast nitric oxide donor.
Reaction of nitric oxide (NO) with L-proline in methanolic sodium methoxide yields a diazeniumdiolate product, C5H7N3O4Na2.CH3OH (PROLI/NO), that can be stabilized in basic solution but thatExpand
Nitrative Inactivation of Thioredoxin-1 and Its Role in Postischemic Myocardial Apoptosis
It is suggested that nitrative inactivation of Trx plays a proapoptotic role under those pathological conditions in which production of reactive nitrogen species is increased and that antinitrating treatment may have therapeutic value in those diseases, such as myocardial ischemia/reperfusion, in which pathological apoptosis is increased. Expand
Inactivation of nitric oxide synthase by substituted aminoguanidines and aminoisothioureas.
A series of substituted aminoguanidines and amino-substituted isothioureas have been examined as inhibitors of nitric oxide (NO) synthase (NOS) isoforms. Each of the agents produced a time- andExpand
Novel phenanthridinone inhibitors of poly(adenosine 5′-diphosphate-ribose) synthetase: Potent cytoprotective and antishock agents*
The novel series of phenanthridinone PARS inhibitors have potent cytoprotective effects in vitro and significant protective effects in shock and reperfusion injury in rodent models in vivo. Expand