Endothelial function and oxidative stress in cardiovascular diseases.
- Y. Higashi, K. Noma, M. Yoshizumi, Y. Kihara
- Biology, MedicineCirculation Journal
- 20 February 2009
This review focuses on recent findings and interaction between endothelium-dependent vasodilation and oxidative stress in cardiovascular diseases.
Effect of Different Intensities of Exercise on Endothelium-Dependent Vasodilation in Humans: Role of Endothelium-Dependent Nitric Oxide and Oxidative Stress
- Chikara Goto, Y. Higashi, I. Nara
- MedicineCirculation
- 5 August 2003
It is suggested that moderate-intensity aerobic exercise augments endothelium-dependent vasodilation in humans through the increased production of nitric oxide and that high-intensity exercise possibly increases oxidative stress.
Physiological role of ROCKs in the cardiovascular system.
- K. Noma, Naotsugu Oyama, J. Liao
- BiologyAmerican Journal of Physiology - Cell Physiology
- 1 March 2006
The precise role of ROCKs in cardiovascular disease remains unknown, but with the recent development of ROCK1- and ROCK2-knockout mice, further dissection of ROCK signaling pathways is now possible.
Rho Kinase (ROCK) Inhibitors
Clinically, inhibition of ROCK pathway is believed to contribute to some of the cardiovascular benefits of statin therapy that are independent of lipid lowering (ie, pleiotropic effects).
Repetition of Ischemic Preconditioning Augments Endothelium-Dependent Vasodilation in Humans: Role of Endothelium-Derived Nitric Oxide and Endothelial Progenitor Cells
- M. Kimura, K. Ueda, Y. Higashi
- Biology, MedicineArteriosclerosis, Thrombosis and Vascular Biology
- 1 June 2007
It is suggested that repetition of late IPC stimulus augments endothelium-dependent vasodilation in humans through increases in nitric oxide production and number of EPCs under a local condition.
Rapid nongenomic actions of thyroid hormone
- Y. Hiroi, Hyung-Hwan Kim, J. Liao
- Biology, MedicineProceedings of the National Academy of Sciences
- 19 September 2006
The activation of PI3-kinase/Akt pathways can mediate some of the rapid, non-TRE effects of TR and suggest that the activation of Akt and eNOS contributes toSome of the acute vasodilatory and neuroprotective effects of thyroid hormone.
Decreased Perivascular Fibrosis but Not Cardiac Hypertrophy in ROCK1+/− Haploinsufficient Mice
- Y. Rikitake, Naotsugu Oyama, J. Liao
- Medicine, BiologyCirculation
- 8 November 2005
Findings indicate ROCK1 is critical for the development of cardiac fibrosis, but not hypertrophy, in response to various pathological conditions and suggest that signaling pathways leading to the hypertrophic and profibrotic response of the heart are distinct.
RhoA/ROCK signaling is essential for multiple aspects of VEGF‐mediated angiogenesis
- B. Bryan, Emily A Dennstedt, D'Amore A. Patricia
- BiologyThe FASEB Journal
- 1 September 2010
It is demonstrated that vascular endothelial growth factor‐A (VEGF) rapidly induces RhoA activation in endothelial cells (ECs), and data indicating that VEGF‐driven angiogenesis is largely mediated through ROCK2 is provided, indicating that Rho/ROCK signaling is an important mediator in a number of angiogenic processes.
Autologous Bone-Marrow Mononuclear Cell Implantation Improves Endothelium-Dependent Vasodilation in Patients With Limb Ischemia
- Y. Higashi, M. Kimura, M. Yoshizumi
- Medicine, BiologyCirculation
- 16 March 2004
It is suggested that autologous bone-marrow mononuclear cell (BM-MNC) implantation augments endothelium-dependent vasodilation in patients with limb ischemia.
ROCK1 mediates leukocyte recruitment and neointima formation following vascular injury.
- K. Noma, Y. Rikitake, J. Liao
- GeologyJournal of Clinical Investigation
- 1 May 2008
It is indicated that ROCK1 in BM-derived cells mediates neointima formation following vascular injury and suggest that ROCK 1 may represent a promising therapeutic target in vascular inflammatory diseases.
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