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Epidermal Growth Factor Receptor

Known as: Transforming Growth Factor alpha Receptor, Receptor, TGF alpha, Receptor, ErbB-1 
A cell surface receptor involved in regulation of cell growth and differentiation. It is specific for EPIDERMAL GROWTH FACTOR and EGF-related… Expand
National Institutes of Health

Related topics

Related topics

27 relations
BIBX 1382EGFR geneEGFR wt AlleleERBB2 gene
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Narrower (5)

EGFR protein, Anopheles gambiaeEGFR protein, humanEgfr protein, Drosophilaepidermal growth factor receptor VIII
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Broader (2)

Growth Factor ReceptorsReceptor Protein-Tyrosine Kinases

Papers overview

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Highly Cited
2008
Highly Cited
2008
Hepatocyte growth factor induces gefitinib resistance of lung adenocarcinoma with epidermal growth factor receptor-activating mutations.
Lung cancer with epidermal growth factor receptor (EGFR)-activating mutations responds favorably to the EGFR tyrosine kinase… Expand
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Review
2006
Review
2006
Epidermal growth factor receptor (EGFR) signaling in cancer.
The epidermal growth factor receptor (EGFR) belongs to the ErbB family of receptor tyrosine kinases (RTK). These trans-membrane… Expand
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Highly Cited
2006
Highly Cited
2006
An Allosteric Mechanism for Activation of the Kinase Domain of Epidermal Growth Factor Receptor
The mechanism by which the epidermal growth factor receptor (EGFR) is activated upon dimerization has eluded definition. We find… Expand
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Review
2006
Review
2006
Epidermal growth factor receptor biology in head and neck cancer.
Epidermal growth factor receptor (EGFR) is overexpressed in several epithelial malignancies, including head and neck squamous… Expand
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Highly Cited
2005
Highly Cited
2005
A comprehensive pathway map of epidermal growth factor receptor signaling
The epidermal growth factor receptor (EGFR) signaling pathway is one of the most important pathways that regulate growth… Expand
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Highly Cited
2005
Highly Cited
2005
Structural basis for inhibition of the epidermal growth factor receptor by cetuximab.
Recent structural studies of epidermal growth factor receptor (EGFR) family extracellular regions have identified an unexpected… Expand
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Highly Cited
2002
Highly Cited
2002
Structure of the Epidermal Growth Factor Receptor Kinase Domain Alone and in Complex with a 4-Anilinoquinazoline Inhibitor*
The crystal structure of the kinase domain from the epidermal growth factor receptor (EGFRK) including forty amino acids from the… Expand
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Highly Cited
1995
Highly Cited
1995
Biological efficacy of a chimeric antibody to the epidermal growth factor receptor in a human tumor xenograft model.
The epidermal growth factor receptor (EGFR) is a protein tyrosine kinase expressed on many types of tumor cells, including breast… Expand
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Highly Cited
1992
Highly Cited
1992
Structural alterations of the epidermal growth factor receptor gene in human gliomas.
The epidermal growth factor receptor (EGFR) gene is amplified in 40% of malignant gliomas, and the amplified genes are frequently… Expand
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Highly Cited
1984
Highly Cited
1984
Human epidermal growth factor receptor cDNA sequence and aberrant expression of the amplified gene in A431 epidermoid carcinoma cells
The complete 1,210-amino acid sequence of the human epidermal growth factor (EGF) receptor precursor, deduced from cDNA clones… Expand
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