FAQ

Epidermal Growth Factor Receptor

Known as: Transforming Growth Factor alpha Receptor, Receptor, TGF alpha, Receptor, ErbB-1 
A cell surface receptor involved in regulation of cell growth and differentiation. It is specific for EPIDERMAL GROWTH FACTOR and EGF-related… (More)

Topic mentions per year

Topic mentions per year

1983-2017
0500100019832017

Related topics

Related topics

24 relations
BIBX 1382EGFR geneEGFR wt AlleleERBB2 gene
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Narrower (4)

EGFR protein, humanEgfr protein, Drosophilaepidermal growth factor receptor (768-775)epidermal growth factor receptor VIII

Broader (2)

Growth Factor ReceptorsReceptor Protein-Tyrosine Kinases

Related mentions per year

Related mentions per year

1936-2018
19401960198020002020
Epidermal Growth Factor Receptor
physiological aspects
agonists
Growth Factor Receptors
Receptor Protein-Tyrosine Kinases
erbB-2 Receptor

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2016
Review
2016
Epidermal growth factor receptor targeting and challenges in glioblastoma.
With the evolution of technology, there is now a deeper understanding of glioblastoma as an inter- and intraheterogeneous disease… (More)
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Review
2016
Review
2016
Resistant mechanisms to BRAF inhibitors in melanoma.
Patients with advanced melanoma have traditionally had very poor prognosis. However, since 2011 better understanding of the… (More)
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Review
2015
Review
2015
Caffeic Acid Phenethyl Ester Is a Potential Therapeutic Agent for Oral Cancer
Head and neck cancers, which affect 650,000 people and cause 350,000 deaths per year, is the sixth leading cancer by cancer… (More)
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Highly Cited
2010
Highly Cited
2010
Gefitinib versus cisplatin plus docetaxel in patients with non-small-cell lung cancer harbouring mutations of the epidermal growth factor receptor (WJTOG3405): an open label, randomised phase 3 trial…
BACKGROUND Patients with non-small-cell lung cancer harbouring mutations in the epidermal growth factor receptor (EGFR) gene… (More)
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Highly Cited
2006
Highly Cited
2006
An Allosteric Mechanism for Activation of the Kinase Domain of Epidermal Growth Factor Receptor
The mechanism by which the epidermal growth factor receptor (EGFR) is activated upon dimerization has eluded definition. We find… (More)
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Highly Cited
2005
Highly Cited
2005
Clinical and biological features associated with epidermal growth factor receptor gene mutations in lung cancers.
BACKGROUND Mutations in the tyrosine kinase (TK) domain of the epidermal growth factor receptor (EGFR) gene in lung cancers are… (More)
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Highly Cited
2005
Highly Cited
2005
A comprehensive pathway map of epidermal growth factor receptor signaling
The epidermal growth factor receptor (EGFR) signaling pathway is one of the most important pathways that regulate growth… (More)
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Highly Cited
2004
Highly Cited
2004
Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib.
BACKGROUND Most patients with non-small-cell lung cancer have no response to the tyrosine kinase inhibitor gefitinib, which… (More)
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Highly Cited
2003
Highly Cited
2003
Efficacy of gefitinib, an inhibitor of the epidermal growth factor receptor tyrosine kinase, in symptomatic patients with non-small cell lung cancer: a randomized trial.
CONTEXT More persons in the United States die from non-small cell lung cancer (NSCLC) than from breast, colorectal, and prostate… (More)
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Highly Cited
1994
Highly Cited
1994
A mutant epidermal growth factor receptor common in human glioma confers enhanced tumorigenicity.
The development and neoplastic progression of human astrocytic tumors appears to result through an accumulation of genetic… (More)
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