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ERBB2 gene

Known as: erbb2 Genes, erbB-2 Gene, Genes, erbB-2 
The erbB-2 gene is a proto-oncogene that codes for the erbB-2 receptor (RECEPTOR, ERBB-2), a protein with structural features similar to the… 
National Institutes of Health

Related topics

Related topics

48 relations
Adenocarcinoma of lung (disorder)Atypical Medullary Breast CarcinomaBreast Carcinoma with Choriocarcinomatous FeaturesCell Proliferation

Broader (1)

Proto-Oncogenes

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2011
Highly Cited
2011
Trastuzumab-DM1 (T-DM1) retains all the mechanisms of action of trastuzumab and efficiently inhibits growth of lapatinib insensitive breast cancer
Trastuzumab (Herceptin®) is currently used as a treatment for patients whose breast tumors overexpress HER2/ErbB2. Trastuzumab… 
Highly Cited
2006
Highly Cited
2006
Statistical methods for characterizing diversity of microbial communities by analysis of terminal restriction fragment length polymorphisms of 16S rRNA genes.
The analysis of terminal restriction fragment length polymorphisms (T-RFLP) of 16S rRNA genes has proven to be a facile means to… 
Highly Cited
2003
Highly Cited
2003
CANON and Anammox in a gas-lift reactor.
Highly Cited
2002
Highly Cited
2002
Comparison of HER-2 status between primary breast cancer and corresponding distant metastatic sites.
BACKGROUND The humanized anti-HER-2 monoclonal antibody trastuzumab (Herceptin) is a new treatment modality for metastatic breast… 
Highly Cited
1994
Highly Cited
1994
Identification of c‐erbB‐3 binding sites for phosphatidylinositol 3′‐kinase and SHC using an EGF receptor/c‐erbB‐3 chimera.
c‐erbB‐3 is a member of the type I (EGF receptor‐related) family of growth factor receptors for which no ligand has been… 
Highly Cited
1990
Highly Cited
1990
Fibroblast-mediated acceleration of human epithelial tumor growth in vivo.
Transformed fibroblasts coinoculated with epithelial cells accelerated the growth and shortened the latency period of human… 
Highly Cited
1989
Highly Cited
1989
Stochastic appearance of mammary tumors in transgenic mice carrying the MMTV/c-neu oncogene
Highly Cited
1989
Highly Cited
1989
Synergistic interaction of p185c-neu and the EGF receptor leads to transformation of rodent fibroblasts
Highly Cited
1989
Highly Cited
1989
Correlation between long-term survival in breast cancer patients and amplification of two putative oncogene-coamplification units: hst-1/int-2 and c-erbB-2/ear-1.
The incidence and association with 10-year survival of amplification in five protooncogenes or transforming genes were… 
Highly Cited
1985
Highly Cited
1985
Down-modulation of an oncogene protein product and reversion of the transformed phenotype by monoclonal antibodies
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